Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Cells Dev. 2021 Jun;166:203683. doi: 10.1016/j.cdev.2021.203683. Epub 2021 Apr 27.
Cellular processes are initiated and regulated by different stimuli, including mechanical forces. Cell membrane mechanosensors represent the first step towards the conversion of mechanical stimuli to a biochemical or electrical response. Mechanosensitive (MS) ion channels form a growing family of ion gating channels that respond to direct physical force or plasma membrane deformations. A number of calcium (Ca) permeable MS channels are known to regulate the initiation, direction, and persistence of cell migration during development and tumour progression. While the evidence that links individual MS ion channels to cell migration is growing, a unified analysis of the molecular mechanisms regulated downstream of MS ion channel activation is lacking. In this review, we describe the MS ion channel families known to regulate cell migration. We discuss the molecular mechanisms that act downstream of MS ion channels with an emphasis on Ca mediated processes. Finally, we propose the future directions and impact of MS ion channel activity in the field of cell migration.
细胞过程是由不同的刺激引发和调节的，包括机械力。细胞膜机械感受器是将机械刺激转化为生化或电反应的第一步。机械敏感 (MS) 离子通道是一个不断增长的离子门控通道家族，它们对直接的物理力或质膜变形作出反应。许多钙 (Ca) 可渗透的 MS 通道已知可调节细胞在发育和肿瘤进展过程中的起始、方向和持续迁移。虽然将单个 MS 离子通道与细胞迁移联系起来的证据不断增加，但缺乏对 MS 离子通道激活下游调节的分子机制的综合分析。在这篇综述中，我们描述了已知调节细胞迁移的 MS 离子通道家族。我们讨论了 MS 离子通道下游的分子机制，重点是 Ca 介导的过程。最后，我们提出了 MS 离子通道活性在细胞迁移领域的未来方向和影响。
