Zhang GuangJun, Levin Michael
Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47906.
Allen Discovery Center at Tufts University, Medford, MA 02155.
Mol Biol Cell. 2025 Feb 1;36(2):pe2. doi: 10.1091/mbc.E23-08-0312.
The cellular electrical signals of living organisms were discovered more than a century ago and have been extensively investigated in the neuromuscular system. Neuronal depolarization and hyperpolarization are essential for our neuromuscular physiological and pathological functions. Bioelectricity is being recognized as an ancient, intrinsic, fundamental property of all living cells, and it is not limited to the neuromuscular system. Instead, emerging evidence supports a view of bioelectricity as an instructional signaling cue for fundamental cellular physiology, embryonic development, regeneration, and human diseases, including cancers. Here, we highlight the current understanding of bioelectricity and share our views on the challenges and perspectives.
一个多世纪前人们就发现了生物体的细胞电信号，并且已经在神经肌肉系统中进行了广泛研究。神经元去极化和超极化对于我们的神经肌肉生理和病理功能至关重要。生物电正被视为所有活细胞古老、内在、基本的特性，并且它并不局限于神经肌肉系统。相反，新出现的证据支持将生物电视为一种用于基本细胞生理学、胚胎发育、再生以及包括癌症在内的人类疾病的指导性信号线索的观点。在此，我们着重介绍当前对生物电的理解，并分享我们对挑战和前景的看法。
