Lainonen H, Marvola M, Hietala P, Parviainen T
Extracta Ltd., Helsinki, Finland.
Pharmacol Toxicol. 1988 Jul;63(1):37-41. doi: 10.1111/j.1600-0773.1988.tb00906.x.
This paper investigates the effect of different storage conditions on the chemical stability, laxative effect and acute toxicity of sennoside solutions. The variables in storage conditions were pH, time and temperature (room temperature or 100 degrees). The chemical stability of sennosides in aqueous solutions was found to be pH-dependent, with the best stability at pH 6.5 (t90. = 8.4 months) and the poorest at pH 8.0 (t90. = 2.5 months). Two years of storage at room temperature did not reduce the laxative potency in mice, regardless of the pH. After 4.25 years of storage the potency declined in alkaline solutions only. The degradation products with laxative potencies are chemically unknown. The acute toxicity of sennoside solutions increased with time during storage, the acid solution being more toxic than either the neutral or alkaline ones.
本文研究了不同储存条件对番泻苷溶液化学稳定性、泻下作用及急性毒性的影响。储存条件的变量包括pH值、时间和温度（室温或100摄氏度）。发现番泻苷在水溶液中的化学稳定性取决于pH值，在pH 6.5时稳定性最佳（t90 = 8.4个月），在pH 8.0时最差（t90 = 2.5个月）。无论pH值如何，在室温下储存两年都不会降低对小鼠的泻下效力。储存4.25年后，仅碱性溶液中的效力下降。具有泻下效力的降解产物在化学上尚不清楚。番泻苷溶液的急性毒性在储存期间随时间增加，酸性溶液比中性或碱性溶液毒性更大。
