Schick Jason, Ritchie Raquel P, Restini Carolina
College of Osteopathic Medicine, Michigan State University, Clinton Township, MI, USA.
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Breast Cancer (Auckl). 2021 Mar 24;15:1178223421995854. doi: 10.1177/1178223421995854. eCollection 2021.
Breast cancer (BC) is the leading cause of cancer death in women and the second-most common cancer. An estimated 281 550 new cases of invasive BC will be diagnosed in women in the United States, and about 43 600 will die during 2021. Continual research has shed light on all disease areas, including tumor classification and biomarkers for diagnosis/prognosis. As research investigations evolve, new classes of drugs are emerging with potential benefits in BC treatment that are covered in this manuscript. The initial sections present updated classification and terminology used for diagnosis and prognosis, which leads to the following topics, discussing the past and present treatments available for BC. Our review will generate interest in exploring the complexity of the cell cycle and its association with cancer biology as part of the plethora of target factors toward developing newer drugs and effective therapeutic management of BC.
乳腺癌（BC）是女性癌症死亡的主要原因，也是第二大常见癌症。据估计，2021年美国将有281550例女性浸润性乳腺癌新病例被诊断出来，约43600人将死亡。持续的研究已阐明了所有疾病领域，包括肿瘤分类以及用于诊断/预后的生物标志物。随着研究的不断发展，新型药物不断涌现，本手稿将涵盖这些药物在乳腺癌治疗中可能带来的益处。开头部分介绍了用于诊断和预后的最新分类和术语，进而引出以下主题，讨论乳腺癌过去和现在可用的治疗方法。我们的综述将激发人们对探索细胞周期的复杂性及其与癌症生物学的关联的兴趣，这是开发新型药物和有效治疗乳腺癌的众多目标因素之一。
