经内镜甲状腺微小乳头状癌手术中应用碳纳米颗粒的临床意义及方法的初步研究。

Preliminary Study on the Clinical Significance and Methods of Using Carbon Nanoparticles in Endoscopic Papillary Thyroid Cancer Surgery.

机构信息

Department of General Surgery, Wenzhou Central Hospital, Wenzhou 325000, Zhejiang, China.

出版信息

Contrast Media Mol Imaging. 2021 Apr 26;2021:6652315. doi: 10.1155/2021/6652315. eCollection 2021.

PURPOSE

The purpose of this study was to find the clinical significance and methods of using CN in endoscopic treatment for PTC.

MATERIALS AND METHODS

A total of 108 cases were randomly enrolled and divided into two groups, with 50 cases in the CN injection group who were injected with CN and 58 cases in the control group with no CN injection. All cases were analyzed with the size of carcinoma, the number of lymph node, and parathyroid gland injury.

RESULTS

All operations were successfully completed. The lymph node dissection number was 274 for the control group and 322 (the rate of black stained was 87%) for the CN injection group. The average number of lymph nodes in the CN injection group was 6.44 ± 2.08, which was significantly higher than that in the control group (4.72 ± 1.89). The control group had a relatively higher incidence of incidental parathyroidectomy, compared to the CN injection group (27.6% in the control group vs. 12% in the CN injection group, =0.045). However, the incidence of hypoparathyroidism failed to show the significant difference between the two groups.

CONCLUSION

Using CN in endoscopic PTC surgery could increase the detection rate of lymph nodes and reduce the injury of parathyroid glands to a certain extent.

目的

本研究旨在探讨 CN 在经内镜甲状腺微小乳头状癌（PTC）治疗中的临床意义和应用方法。

材料与方法

将 108 例患者随机分为 CN 注射组（50 例）和对照组（58 例），CN 注射组于术区注射 CN，对照组不注射 CN。分析两组患者的肿瘤大小、淋巴结转移个数、甲状旁腺损伤情况。

结果

所有手术均顺利完成。对照组淋巴结清扫数目为 274 枚，CN 注射组为 322 枚（黑染率为 87%）。CN 注射组平均每例清扫淋巴结 6.44±2.08 枚，明显多于对照组（4.72±1.89 枚）。对照组甲状旁腺误伤率明显高于 CN 注射组（27.6%比 12%，=0.045），但两组术后甲状旁腺功能低下发生率差异无统计学意义。