Chen Xueping, Feng Weihua, Ou Ruwei, Liu Jiao, Yang Jing, Fu Jiajia, Cao Bei, Chen Yongping, Wei Qianqian, Shang Huifang
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Division of Clinical Immunology, West China Hospital, Sichuan University, Chengdu, China.
Front Aging Neurosci. 2021 Apr 30;13:617370. doi: 10.3389/fnagi.2021.617370. eCollection 2021.
Accumulating evidence has revealed that peripheral immunity is involved in Parkinson's disease (PD). However, the results regarding the percentage of T-cell subsets are inconsistent, and the changes of immunoglobins levels have been seldom studied in PD patients.
Serum levels of the percentage of T-cell subsets and immunoglobulins were measured in 761 PD patients and 761 age- and gender-matched healthy controls. The correlations between the variables of peripheral immune activation (PIA) and the clinical characteristics of PD were analyzed using correlation analysis.
The pooled results showed that PD patients had higher proportional levels of CD3+ T and CD4+ T lymphocytes than healthy controls. CD8+ T cell percentages were similar in PD patients and controls, and the CD4/CD8 ratio was significantly higher in the PD population. No significant differences in IgG, IgA, or IgM levels between these two groups were found. CD4+ T cell percentage was inversely correlated with the H&Y stage, and IgG level was positively correlated with disease duration and UPDRS part III. Subgroup analyses showed that these associations existed in female patients, but not in male patients.
The enhanced immune activation in the peripheral system is indicated in PD, and dynamic alterations in CD4+ T cell percentage and IgG level suggest an active role for peripheral immunity in the disease progression, especially in female PD patients.
越来越多的证据表明外周免疫与帕金森病（PD）有关。然而，关于T细胞亚群百分比的结果并不一致，且很少有研究探讨PD患者免疫球蛋白水平的变化。
检测了761例PD患者和761例年龄及性别匹配的健康对照者血清中T细胞亚群百分比和免疫球蛋白水平。采用相关性分析对外周免疫激活（PIA）变量与PD临床特征之间的相关性进行分析。
汇总结果显示，PD患者的CD3⁺T和CD4⁺T淋巴细胞比例水平高于健康对照者。PD患者和对照者的CD8⁺T细胞百分比相似，且PD人群的CD4/CD8比值显著更高。两组之间的IgG、IgA或IgM水平未发现显著差异。CD4⁺T细胞百分比与H&Y分期呈负相关，IgG水平与病程和UPDRS第三部分呈正相关。亚组分析表明，这些关联存在于女性患者中，而不存在于男性患者中。
PD提示外周系统免疫激活增强，CD4⁺T细胞百分比和IgG水平的动态变化表明外周免疫在疾病进展中起积极作用，尤其是在女性PD患者中。
