Cao Bei, Chen Xueping, Zhang Lingyu, Wei Qianqian, Liu Hui, Feng Weihua, Chen Yongping, Shang Huifang
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Front Neurol. 2020 Jul 7;11:658. doi: 10.3389/fneur.2020.00658. eCollection 2020.
α-synuclein is involved in the pathogenesis of multiple system atrophy (MSA) and can be regulated by peripheral immune activation (PIA). We aimed to clarify the correlations between PIA and the prevalence of MSA and to analyze the role of PIA in the progression of the disease. A total of 321 patients with probable MSA and 321 age- and gender-matched healthy controls were included in this study. Lymphocyte subsets, including CD3, CD4, and CD8 cells, and the levels of immunoglobulins IgG, IgM, and IgA were evaluated. The proportions of CD3 and CD4 T-lymphocytes were significantly increased in MSA patients compared with those of normal controls. In addition, the ratio of CD4 to CD8 cells was significantly increased in male MSA patients and IgG concentrations were decreased in female MSA patients. Furthermore, the concentrations of IgM in female MSA patients were dynamically different at various disease stages and gradually decreased from the early stage until the end stage of the disease ( = 0.029). Other detected immunological indexes were not significantly different during the entire disease course. In this study, high proportions of CD3 and CD4 T-lymphocytes and decreased IgG levels were associated with an increased risk for MSA in a Chinese patient population. In addition, PIA may be involved in the progression of MSA.
α-突触核蛋白参与多系统萎缩（MSA）的发病机制，且可受外周免疫激活（PIA）调控。我们旨在阐明PIA与MSA患病率之间的相关性，并分析PIA在该疾病进展中的作用。本研究共纳入321例可能患有MSA的患者以及321例年龄和性别匹配的健康对照。评估了淋巴细胞亚群，包括CD3、CD4和CD8细胞，以及免疫球蛋白IgG、IgM和IgA的水平。与正常对照相比，MSA患者中CD3和CD4 T淋巴细胞的比例显著增加。此外，男性MSA患者中CD4与CD8细胞的比例显著增加，而女性MSA患者中IgG浓度降低。此外，女性MSA患者在疾病各阶段的IgM浓度存在动态差异，且从疾病早期直至末期逐渐降低（P = 0.029）。在整个病程中，其他检测的免疫指标无显著差异。在本研究中，高比例的CD3和CD4 T淋巴细胞以及降低的IgG水平与中国患者群体中MSA风险增加相关。此外，PIA可能参与MSA的进展。
