Natoli Silvia
Department of Clinical Science and Translational Medicine and Unit of Pain Therapy, Polyclinic of Tor Vergata, University of Rome, Tor Vergata, Rome, Italy.
Drugs Context. 2021 Apr 23;10. doi: 10.7573/dic.2020-12-8. eCollection 2021.
Ketamine is an anaesthetic agent with a unique dissociative profile and pharmacological effects ranging from the induction and maintenance of anaesthesia to analgesia and sedation, depending on the dose. This article provides information for the clinical use of ketamine in anaesthesia, in both conventional and special circumstances.
This is a non-systematic review of the literature, through a PubMed search up to February 2021.
With a favourable pharmacokinetic profile, ketamine is used in hospital and prehospital settings for emergency situations. It is suitable for patients with many heart conditions and, unlike other anaesthetics, its potential for cardiorespiratory depression is low. Furthermore, it may be used when venous access is difficult as it may be administered through various routes. Ketamine is the anaesthetic of choice for patients with bronchospasm thanks to its bronchodilatory and anti-inflammatory properties.
With a favourable pharmacokinetic profile, ketamine is used in hospital and prehospital settings for emergency situations and is suitable for patients with many cardiac and respiratory conditions.
氯胺酮是一种具有独特解离特性的麻醉剂，其药理作用取决于剂量，涵盖从麻醉诱导与维持到镇痛和镇静等多个方面。本文提供了氯胺酮在常规及特殊情况下麻醉临床应用的相关信息。
这是一项通过检索截至2021年2月的PubMed文献进行的非系统性综述。
氯胺酮具有良好的药代动力学特性，在医院和院前环境中用于紧急情况。它适用于多种心脏疾病患者，与其他麻醉剂不同，其导致心肺抑制的可能性较低。此外，当静脉通路困难时也可使用，因为它可以通过多种途径给药。由于其支气管扩张和抗炎特性，氯胺酮是支气管痉挛患者的首选麻醉剂。
氯胺酮具有良好的药代动力学特性，在医院和院前环境中用于紧急情况，适用于多种心脏和呼吸疾病患者。
