冠状动脉狭窄患者在经皮冠状动脉介入治疗前后的最佳预后评估：对在2020年TCT Connect会议上发表的TARGET FFR和DEFINE-FLOW试验的评论
Optimal Prognostication of Patients with Coronary Stenoses in the Pre- and Post-PCI setting: Comments on TARGET FFR and DEFINE-FLOW Trials Presented at TCT Connect 2020.
作者信息
Seitz Andreas, Baumann Stefan, Sechtem Udo, Ong Peter
机构信息
Department of Cardiology and Angiology, Robert-Bosch-Krankenhaus Stuttgart, Germany.
Department of Cardiology, Pneumology and Angiology, University Hospital Mannheim Mannheim, Germany.
出版信息
Eur Cardiol. 2021 Apr 27;16:e17. doi: 10.15420/ecr.2021.04. eCollection 2021 Feb.
Abstract
The body of evidence for the use of coronary physiology assessments to guide percutaneous coronary intervention (PCI) has been growing continuously in recent decades. Two studies presented during TCT Connect 2020 added insights into the prognostic value of coronary physiology measurements in pre- and post-PCI settings. The first study, TARGET FFR, assessed whether a post-PCI fractional flow reserve (FFR)-guided incremental optimisation strategy (PIOS) was superior to angiography-guided PCI. The second study, DEFINE-FLOW, assessed the course of stenoses with fractional and coronary flow reserve (FFR+/CFR-) discordance when treated medically. This article summarises the main results from the TARGET FFR and the DEFINE-FLOW trials and puts them into the context of the existing literature.
摘要
近几十年来，使用冠状动脉生理学评估来指导经皮冠状动脉介入治疗（PCI）的证据一直在不断增加。在2020年TCT Connect会议上发表的两项研究，为冠状动脉生理学测量在PCI术前和术后环境中的预后价值提供了新的见解。第一项研究，TARGET FFR，评估了PCI术后基于血流储备分数（FFR）引导的增量优化策略（PIOS）是否优于血管造影引导的PCI。第二项研究，DEFINE-FLOW，评估了药物治疗时存在血流储备分数与冠状动脉血流储备不一致（FFR+/CFR-）的狭窄病变的病程。本文总结了TARGET FFR和DEFINE-FLOW试验的主要结果，并将其置于现有文献的背景中。
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