Sun Yajie, Feng Xiangru, Wan Chao, Lovell Jonathan F, Jin Honglin, Ding Jianxun
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Asian J Pharm Sci. 2021 Mar;16(2):129-132. doi: 10.1016/j.ajps.2020.05.004. Epub 2020 Jun 24.
Cancer immunotherapy, which suppresses cancer progression by activating the anti-cancer immunity of patients, shows utility in treating multiple types of cancers. Immunogenic cell death (ICD) induced by most clinical treatment modalities plays a critical role in promoting cancer immunotherapy by releasing tumor-associated antigens and neoantigens and exposing "danger signals" to stimulate immune cells. This comment article presents the different roles of nanoparticles in various treatment modalities of cancers, including chemotherapy, radiotherapy, photodynamic and photothermal therapies, and therapy with radiated tumor cell-released nanoparticles, which often activate anti-cancer immunological effects by inducing ICD of cancer cells, and highlights the challenges and opportunities of ICD-related cancer immunotherapy in the clinic.
癌症免疫疗法通过激活患者的抗癌免疫力来抑制癌症进展，在治疗多种类型的癌症中显示出效用。大多数临床治疗方式诱导的免疫原性细胞死亡（ICD）通过释放肿瘤相关抗原和新抗原并暴露“危险信号”以刺激免疫细胞，在促进癌症免疫疗法中起着关键作用。这篇评论文章介绍了纳米颗粒在癌症的各种治疗方式中的不同作用，包括化疗、放疗、光动力和光热疗法，以及用辐射肿瘤细胞释放的纳米颗粒进行治疗，这些治疗方式通常通过诱导癌细胞的ICD来激活抗癌免疫效应，并强调了临床中与ICD相关的癌症免疫疗法的挑战和机遇。
