胃颗粒细胞瘤与腺癌共存：1例罕见病例报告

Granular cell tumor coexisting with adenocarcinoma in the stomach: Report of a rare case.

作者信息

Nitta Toshikatsu, Ohta Masato, Kataoka Jun, Ishii Masatsugu, Ueda Yasuhiko, Senpuku Sadakatsu, Takeshita Atsushi, Ishibashi Takashi

机构信息

Division of Surgery Gastroentelogical Center, Medico Shunju Shiroyama Hospital, Osaka, Japan.

Department of Gastroenterological Surgery Osaka Medical College, Osaka, Japan.

出版信息

Ann Med Surg (Lond). 2021 Apr 26;65:102271. doi: 10.1016/j.amsu.2021.102271. eCollection 2021 May.

DOI:10.1016/j.amsu.2021.102271

PMID:33996044

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8100089/

Abstract

INTRODUCTION

and importance: Granular cell tumor (GCT) is a benign, mesenchymal tumor that originates from Schwann cells.

CASE PRESENTATION

A 75-year-old Japanese woman was referred to our hospital due to epigastric discomfort. Upper gastrointestinal endoscopy revealed an ulcerated cancer lesion, approximately 1.2 cm in diameter, at the angle of the stomach in the posterior gastric wall and a yellowish submucosal tumor, 5 mm in diameter, near an anal ulcerated lesion. Based on these findings, the patient was scheduled for laparoscopic distal gastrectomy and lymph node dissection. The pathological diagnosis was a moderately differentiated tubular adenocarcinoma invading mucosal stroma without lymph node metastasis and GCT in the stomach. Tumor cells were positive for S-100 and were consistent with the characteristics of GCT.

CLINICAL DISCUSSION

To the best of our knowledge, this is an extremely rare case with reports of only 6 cases of such a combination, including our case.

CONCLUSIONS

We believe that the coexistence of a GCT and gastric cancer in our patient was accidental and that there was no relation between them.

摘要

引言

及重要性：颗粒细胞瘤（GCT）是一种起源于施万细胞的良性间叶组织肿瘤。

病例介绍

一名75岁的日本女性因上腹部不适转诊至我院。上消化道内镜检查发现胃后壁胃角处有一个直径约1.2厘米的溃疡型癌病灶，以及一个直径5毫米的黄色黏膜下肿瘤，靠近肛门溃疡病灶。基于这些发现，患者计划接受腹腔镜远端胃切除术和淋巴结清扫术。病理诊断为中度分化管状腺癌侵犯黏膜下层且无淋巴结转移，以及胃内颗粒细胞瘤。肿瘤细胞S-100呈阳性，符合颗粒细胞瘤的特征。