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用[病原体名称]的外膜蛋白进行鼻内接种可诱导针对恙虫病的保护性免疫。 （原文中“of”后面缺少具体内容，这里补充了“病原体名称”以便使译文更完整通顺）

Intranasal Vaccination with Outer-Membrane Protein of induces Protective Immunity Against Scrub Typhus.

作者信息

Park Sung-Moo, Gu Min Jeong, Ju Young-Jun, Cheon In Su, Hwang Kyu-Jam, Gill Byoungchul, Shim Byoung-Shik, Jeong Hang-Jin, Son Young Min, Choi Sangho, Jeung Woonhee, Han Seung Hyun, Chu Hyuk, Yun Cheol-Heui

机构信息

Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.

Laboratory Sciences Division, International Vaccine Institute, Seoul 08826, Korea.

出版信息

Immune Netw. 2020 Dec 3;21(2):e14. doi: 10.4110/in.2021.21.e14. eCollection 2021 Apr.

DOI:10.4110/in.2021.21.e14
PMID:33996170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8099613/
Abstract

Scrub typhus develops after the individual is bitten by a trombiculid mite infected with . Since it has been reported that pneumonia is frequently observed in patients with scrub typhus, we investigated whether intranasal (i.n.) vaccination with the outer membrane protein of (OMPOT) would induce a protective immunity against infection. It was particular interest that when mice were infected with , the bacteria disseminated into the lungs, causing pneumonia. The i.n. vaccination with OMPOT induced IgG responses in serum and bronchoalveolar lavage (BAL) fluid. The anti- IgA Abs in BAL fluid after the vaccination showed a high correlation of the protection against . The vaccination induced strong Ag-specific Th1 and Th17 responses in the both spleen and lungs. In conclusion, the current study demonstrated that i.n. vaccination with OMPOT elicited protective immunity against scrub typhus in mouse with infection causing subsequent pneumonia.

摘要

恙虫病立克次体感染的个体被恙螨叮咬后会患上恙虫病。由于已有报道称恙虫病患者经常出现肺炎，我们研究了用恙虫病东方体的外膜蛋白（OMPOT）进行鼻内（i.n.）接种是否会诱导针对恙虫病东方体感染的保护性免疫。特别值得关注的是，当小鼠感染恙虫病东方体时，细菌会扩散到肺部，引发肺炎。用OMPOT进行鼻内接种可在血清和支气管肺泡灌洗（BAL）液中诱导IgG反应。接种后BAL液中的抗恙虫病东方体IgA抗体与针对恙虫病东方体的保护作用高度相关。该接种在脾脏和肺部均诱导了强烈的抗原特异性Th1和Th17反应。总之，当前研究表明，用OMPOT进行鼻内接种可在感染恙虫病东方体并导致后续肺炎的小鼠中引发针对恙虫病的保护性免疫。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ee/8099613/9d72c8ddf59c/in-21-e14-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ee/8099613/7cd63143550d/in-21-e14-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ee/8099613/8b3f515f85d1/in-21-e14-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ee/8099613/88291c23e04e/in-21-e14-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ee/8099613/0b35bd6cad44/in-21-e14-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ee/8099613/9d72c8ddf59c/in-21-e14-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ee/8099613/7cd63143550d/in-21-e14-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ee/8099613/8b3f515f85d1/in-21-e14-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ee/8099613/88291c23e04e/in-21-e14-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ee/8099613/0b35bd6cad44/in-21-e14-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ee/8099613/9d72c8ddf59c/in-21-e14-g005.jpg

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