Yadav Bhupender, Pal Sonali, Rubstov Yury, Goel Akul, Garg Manoj, Pavlyukov Marat, Pandey Amit Kumar
Amity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, India.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, 117997 Moscow, Russian Federation.
Mol Ther Nucleic Acids. 2021 Apr 2;24:728-742. doi: 10.1016/j.omtn.2021.03.018. eCollection 2021 Jun 4.
Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to recurrence. This review outlines the present status of specific involvement of lncRNAs in GBM pathogenesis, with a focus on their association with key molecular and cellular regulatory mechanisms. Also, we highlighted the potential of different novel RNA-based strategies that may be beneficial for therapeutic purposes.
多形性胶质母细胞瘤（GBM）是成年患者中最常见且侵袭性最强的胶质瘤亚型。在GBM中，许多长链非编码RNA（lncRNA）失调或差异表达。这些lncRNA在GBM细胞中具有独特的调控功能，范围从高侵袭/迁移到复发。本综述概述了lncRNA在GBM发病机制中具体参与的现状，重点关注它们与关键分子和细胞调控机制的关联。此外，我们强调了不同的新型基于RNA的策略在治疗方面可能具有的潜力。
