与胶质母细胞瘤相关的长链非编码RNA：从转录噪音到在治疗中具有潜在作用的新型调节因子
LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics.
作者信息
Yadav Bhupender, Pal Sonali, Rubstov Yury, Goel Akul, Garg Manoj, Pavlyukov Marat, Pandey Amit Kumar
机构信息
Amity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, India.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, 117997 Moscow, Russian Federation.
出版信息
Mol Ther Nucleic Acids. 2021 Apr 2;24:728-742. doi: 10.1016/j.omtn.2021.03.018. eCollection 2021 Jun 4.
Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to recurrence. This review outlines the present status of specific involvement of lncRNAs in GBM pathogenesis, with a focus on their association with key molecular and cellular regulatory mechanisms. Also, we highlighted the potential of different novel RNA-based strategies that may be beneficial for therapeutic purposes.
多形性胶质母细胞瘤（GBM）是成年患者中最常见且侵袭性最强的胶质瘤亚型。在GBM中，许多长链非编码RNA（lncRNA）失调或差异表达。这些lncRNA在GBM细胞中具有独特的调控功能，范围从高侵袭/迁移到复发。本综述概述了lncRNA在GBM发病机制中具体参与的现状，重点关注它们与关键分子和细胞调控机制的关联。此外，我们强调了不同的新型基于RNA的策略在治疗方面可能具有的潜力。
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