文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

胰腺癌中WNT配体依赖性

WNT Ligand Dependencies in Pancreatic Cancer.

作者信息

Aguilera Kristina Y, Dawson David W

机构信息

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, United States.

Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at University of California, Los Angeles, CA, United States.

出版信息

Front Cell Dev Biol. 2021 Apr 28;9:671022. doi: 10.3389/fcell.2021.671022. eCollection 2021.

DOI:10.3389/fcell.2021.671022
PMID:33996827
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8113755/
Abstract

WNT signaling promotes the initiation and progression of pancreatic ductal adenocarcinoma (PDAC) through wide-ranging effects on cellular proliferation, survival, differentiation, stemness, and tumor microenvironment. Of therapeutic interest is a genetically defined subset of PDAC known to have increased WNT/β-catenin transcriptional activity, growth dependency on WNT ligand signaling, and response to pharmacologic inhibitors of the WNT pathway. Here we review mechanisms underlying WNT ligand addiction in pancreatic tumorigenesis, as well as the potential utility of therapeutic approaches that functionally antagonize WNT ligand secretion or frizzled receptor binding.

摘要

WNT信号通路通过对细胞增殖、存活、分化、干性和肿瘤微环境产生广泛影响，促进胰腺导管腺癌（PDAC）的发生和发展。具有治疗意义的是一类基因定义的PDAC亚群，已知其WNT/β-连环蛋白转录活性增加，生长依赖于WNT配体信号传导，并且对WNT通路的药理抑制剂有反应。在此，我们综述了胰腺肿瘤发生过程中WNT配体成瘾的潜在机制，以及在功能上拮抗WNT配体分泌或卷曲受体结合的治疗方法的潜在效用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/535d/8113755/c602097efcc7/fcell-09-671022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/535d/8113755/c602097efcc7/fcell-09-671022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/535d/8113755/c602097efcc7/fcell-09-671022-g001.jpg

相似文献

[1]
WNT Ligand Dependencies in Pancreatic Cancer.

Front Cell Dev Biol. 2021-4-28

[2]
WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma.

Oncogene. 2013-2-18

[3]
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.

Proc Natl Acad Sci U S A. 2013-7-11

[4]
Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand-Addicted Pancreatic Cancer.

Mol Cancer Ther. 2022-6-1

[5]
The ubiquitin ligase RNF43 downregulation increases membrane expression of frizzled receptor in pancreatic ductal adenocarcinoma.

Tumour Biol. 2016-1

[6]
Characterization of RNF43 frameshift mutations that drive Wnt ligand- and R-spondin-dependent colon cancer.

J Pathol. 2022-5

[7]
Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.

Nat Med. 2016-11-21

[8]
Hyperglycemia Promotes Pancreatic Cancer Initiation and Progression by Activating the Wnt/β-Catenin Signaling Pathway.

Anticancer Agents Med Chem. 2021

[9]
Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer.

Mol Cancer Res. 2015-11

[10]
Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth.

Adv Sci (Weinh). 2022-10

引用本文的文献

[1]
Pathway-Specific Genomic Alterations in Pancreatic Cancer Across Populations at Risk.

Int J Mol Sci. 2025-8-8

[2]
Establishing 3D organoid models from patient-derived conditionally reprogrammed cells to bridge preclinical and clinical insights in pancreatic cancer.

Mol Cancer. 2025-6-3

[3]
SUMOylation substrate encoding genes as prognostic biomarkers in pancreatic ductal adenocarcinoma with functional assessment of .

Front Pharmacol. 2025-4-16

[4]
Wnt signaling in cancer: from biomarkers to targeted therapies and clinical translation.

Mol Cancer. 2025-4-2

[5]
Isoleucyl-tRNA synthetase 2 promotes pancreatic ductal adenocarcinoma proliferation and metastasis by stabilizing β-catenin.

Genes Dis. 2024-7-24

[6]
Cancer-associated fibroblasts promote growth and dissemination of esophageal squamous cell carcinoma cells by secreting WNT family member 5A.

Mol Cell Biochem. 2025-2-15

[7]
Wnt Pathway-Targeted Therapy in Gastrointestinal Cancers: Integrating Benchside Insights with Bedside Applications.

Cells. 2025-1-24

[8]
Barriers and opportunities in pancreatic cancer immunotherapy.

NPJ Precis Oncol. 2024-9-12

[9]
Canonical WNT/β-catenin signaling upregulates aerobic glycolysis in diverse cancer types.

Mol Biol Rep. 2024-7-6

[10]
LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance.

Int J Biol Sci. 2024

本文引用的文献

[1]
Cancer Statistics, 2021.

CA Cancer J Clin. 2021-1

[2]
Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.

Diabetes Care. 2021-1

[3]
Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells.

Mol Med Rep. 2021-1

[4]
Blockers of Wnt3a, Wnt10a, or β-Catenin Prevent Chemotherapy-Induced Neuropathic Pain In Vivo.

Neurotherapeutics. 2021-1

[5]
The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition.

Cancer Res. 2020-12-15

[6]
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.

Cell Stem Cell. 2020-11-5

[7]
Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer.

Clin Cancer Res. 2020-10-15

[8]
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target.

Nat Commun. 2020-7-3

[9]
Application of porcupine inhibitors in stem cell fate determination.

Chem Biol Drug Des. 2020-10

[10]
Wnts and the hallmarks of cancer.

Cancer Metastasis Rev. 2020-9

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索