再生医学与组织工程在内镜黏膜下剥离术后预防食管狭窄方面的进展

Zhou Xian-Bin, Xu Shi-Wen, Ye Li-Ping, Mao Xin-Li, Chen Ya-Hong, Wu Jian-Fen, Cai Yue, Wang Yi, Wang Li, Li Shao-Wei

Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, LinHai, Zhejiang, China.

Wenzhou Medical University, Wenzhou, Zhejiang, China.

Regen Ther. 2021 Feb 3;17:51-60. doi: 10.1016/j.reth.2021.01.003. eCollection 2021 Jun.

Endoscopic submucosal dissection (ESD) has been widely accepted as an effective treatment for early esophageal cancer. However, post-ESD esophageal stricture remains a thorny issue. We herein review many strategies for preventing post-ESD esophageal stricture, as well as discuss their strengths and weaknesses. These strategies include pharmacological prophylaxis, esophageal stent and tissue engineering and regenerative medicine treatment. In this review, we summarize these studies and discuss the underlying progress and future directions of tissue engineering and regenerative medicine treatment.

内镜黏膜下剥离术（ESD）已被广泛认可为早期食管癌的有效治疗方法。然而，ESD术后食管狭窄仍然是一个棘手的问题。我们在此回顾了多种预防ESD术后食管狭窄的策略，并讨论了它们的优缺点。这些策略包括药物预防、食管支架以及组织工程和再生医学治疗。在本综述中，我们总结了这些研究，并讨论了组织工程和再生医学治疗的潜在进展及未来方向。