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Murine models for heart failure: Their creation and applicability to human still require critical and careful considerations.

作者信息

Pfeiffer Jessica, Lorenz Kristina

机构信息

Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, 97078 Würzburg, Germany.

Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V, Bunsen-Kirchhoff-Str. 11, 44139 Dortmund, Germany.

出版信息

Int J Cardiol Heart Vasc. 2021 Apr 21;34:100781. doi: 10.1016/j.ijcha.2021.100781. eCollection 2021 Jun.

DOI:10.1016/j.ijcha.2021.100781
PMID:33997255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8091868/
Abstract
摘要

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Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects.在核质界面干扰 ERK 二聚体化可靶向病理性 ERK1/2 信号传导而无心脏毒性副作用。
Nat Commun. 2020 Apr 7;11(1):1733. doi: 10.1038/s41467-020-15505-4.
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Small animal models of heart failure.心力衰竭的小动物模型。
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