Bhinge Somnath D, Bhutkar Mangesh A, Randive Dheeraj S, Wadkar Ganesh H, Todkar Sachin S, Savali Anil S, Chittapurkar Hariprassanna R
Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, 415 404, India.
Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, 415 404, India.
Heliyon. 2021 Apr 27;7(4):e06903. doi: 10.1016/j.heliyon.2021.e06903. eCollection 2021 Apr.
The intent of the present investigation was to explore the utility of alcoholic and aqueous extract of L. as hair growth promoter along with anti-lice and antidandruff activity. A filter paper diffusion approach was employed for screening of the pediculocidal and ovicidal activity. Albino mice, preselected for their telogen phase of hair growth were used during the study. The prepared extracts, Minoxidil and control were applied over shaved skin surface on to the backs of mice to assess telogen to anagen transition. The qualitative and quantitative analysis was performed. The outcome of the studies revealed that L. alcoholic and aqueous extracts exhibited prominent anti-lice activity. The transition of telogen to anagen phase of the number of anagen hair follicle was observed in approximately 45, 27 and 51% of animals treated with alcoholic and aqueous extract of L., and Minoxidil, respectively, which suggest the hair growth promoting potential of the extract of L. Also, 3 % L. alcoholic extracts exhibited a potent antidandruff activity against fungal strains tested. Maltol, was identified as a principal phytoconstituent in the alcoholic extract. The findings greatly suggest anti-lice, antidandruff and hair growth promoting potential of the extract of L.
本研究的目的是探索薰衣草酒精提取物和水提取物作为头发生长促进剂以及抗虱和去屑活性的效用。采用滤纸扩散法筛选杀虱和杀卵活性。在研究过程中使用了预先选择处于休止期毛发生长阶段的白化小鼠。将制备的提取物、米诺地尔和对照涂抹在小鼠背部剃毛的皮肤表面，以评估休止期到生长期的转变。进行了定性和定量分析。研究结果表明，薰衣草酒精提取物和水提取物表现出显著的抗虱活性。分别用薰衣草酒精提取物、水提取物和米诺地尔处理的动物中，约45%、27%和51%观察到生长期毛囊数量从休止期向生长期的转变，这表明薰衣草提取物具有促进头发生长的潜力。此外，3%的薰衣草酒精提取物对测试的真菌菌株表现出强效去屑活性。麦芽酚被确定为酒精提取物中的主要植物成分。这些发现有力地表明了薰衣草提取物具有抗虱、去屑和促进头发生长的潜力。
