• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于骨科应用的增材制造镍钛合金植入物的设计与力学性能综述

A Review on Design and Mechanical Properties of Additively Manufactured NiTi Implants for Orthopedic Applications.

作者信息

Zhang Yintao, Attarilar Shokouh, Wang Liqiang, Lu Weijie, Yang Junlin, Fu Yuanfei

机构信息

State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Department of Pediatric Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200092, China.

出版信息

Int J Bioprint. 2021 Apr 15;7(2):340. doi: 10.18063/ijb.v7i2.340. eCollection 2021.

DOI:10.18063/ijb.v7i2.340
PMID:33997434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8114098/
Abstract

NiTi alloy has a wide range of applications as a biomaterial due to its high ductility, low corrosion rate, and favorable biocompatibility. Although Young's modulus of NiTi is relatively low, it still needs to be reduced; one of the promising ways is by introducing porous structure. Traditional manufacturing processes, such as casting, can hardly produce complex porous structures. Additive manufacturing (AM) is one of the most advanced manufacturing technologies that can solve impurity issues, and selective laser melting (SLM) is one of the well-known methods. This paper reviews the developments of AM-NiTi with a particular focus on SLM-NiTi utilization in biomedical applications. Correspondingly, this paper aims to describe the three key factors, including powder preparation, processing parameters, and gas atmosphere during the overall process of porous NiTi. The porous structure design is of vital importance, so the unit cell and pore parameters are discussed. The mechanical properties of SLM-NiTi, such as hardness, compressive strength, tensile strength, fatigue behavior, and damping properties and their relationship with design parameters are summarized. In the end, it points out the current challenges. Considering the increasing application of NiTi implants, this review paper may open new frontiers for advanced and modern designs.

摘要

由于具有高延展性、低腐蚀速率和良好的生物相容性，镍钛合金作为生物材料有着广泛的应用。尽管镍钛合金的杨氏模量相对较低，但仍需要进一步降低；一种很有前景的方法是引入多孔结构。传统制造工艺，如铸造，很难制造出复杂的多孔结构。增材制造（AM）是能够解决杂质问题的最先进制造技术之一，选择性激光熔化（SLM）是其中一种广为人知的方法。本文综述了增材制造镍钛合金的发展情况，特别关注选择性激光熔化镍钛合金在生物医学应用中的利用。相应地，本文旨在描述多孔镍钛合金整个过程中的三个关键因素，包括粉末制备、工艺参数和气体气氛。多孔结构设计至关重要，因此对晶胞和孔隙参数进行了讨论。总结了选择性激光熔化镍钛合金的力学性能，如硬度、抗压强度、抗拉强度、疲劳行为和阻尼性能及其与设计参数的关系。最后，指出了当前面临的挑战。考虑到镍钛合金植入物的应用日益增加，这篇综述论文可能为先进和现代设计开辟新的领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/566703b2da78/IJB-7-2-340-g031.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/bdd49ceb9a16/IJB-7-2-340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/9eb3cb5a4dad/IJB-7-2-340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/17eaf171bd80/IJB-7-2-340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/b3621cc17e55/IJB-7-2-340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/a6d69941aa87/IJB-7-2-340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/214c54a230d9/IJB-7-2-340-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/1cb9de5d8d9c/IJB-7-2-340-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/0042a2985292/IJB-7-2-340-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/a16a422bd331/IJB-7-2-340-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/06e6688419dc/IJB-7-2-340-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/f1cc748e0139/IJB-7-2-340-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/271aaa1956cd/IJB-7-2-340-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/4dd148203dad/IJB-7-2-340-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/bf7ebb3829df/IJB-7-2-340-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/9c1870f5dbde/IJB-7-2-340-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/3eec3b7e4aac/IJB-7-2-340-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/40bc4f3ab51e/IJB-7-2-340-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/29e6264d7c7b/IJB-7-2-340-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/e20ff5472ce3/IJB-7-2-340-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/2f5b15554896/IJB-7-2-340-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/38c8859b76f3/IJB-7-2-340-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/eb2cbf162c9a/IJB-7-2-340-g023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/a59dd8fcecb0/IJB-7-2-340-g024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/e7d6e9e96dac/IJB-7-2-340-g025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/71aff77067c9/IJB-7-2-340-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/d9d60198377d/IJB-7-2-340-g027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/d0345614d773/IJB-7-2-340-g028.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/79610943467c/IJB-7-2-340-g029.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/87581aee3f31/IJB-7-2-340-g030.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/566703b2da78/IJB-7-2-340-g031.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/bdd49ceb9a16/IJB-7-2-340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/9eb3cb5a4dad/IJB-7-2-340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/17eaf171bd80/IJB-7-2-340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/b3621cc17e55/IJB-7-2-340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/a6d69941aa87/IJB-7-2-340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/214c54a230d9/IJB-7-2-340-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/1cb9de5d8d9c/IJB-7-2-340-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/0042a2985292/IJB-7-2-340-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/a16a422bd331/IJB-7-2-340-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/06e6688419dc/IJB-7-2-340-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/f1cc748e0139/IJB-7-2-340-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/271aaa1956cd/IJB-7-2-340-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/4dd148203dad/IJB-7-2-340-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/bf7ebb3829df/IJB-7-2-340-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/9c1870f5dbde/IJB-7-2-340-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/3eec3b7e4aac/IJB-7-2-340-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/40bc4f3ab51e/IJB-7-2-340-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/29e6264d7c7b/IJB-7-2-340-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/e20ff5472ce3/IJB-7-2-340-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/2f5b15554896/IJB-7-2-340-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/38c8859b76f3/IJB-7-2-340-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/eb2cbf162c9a/IJB-7-2-340-g023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/a59dd8fcecb0/IJB-7-2-340-g024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/e7d6e9e96dac/IJB-7-2-340-g025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/71aff77067c9/IJB-7-2-340-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/d9d60198377d/IJB-7-2-340-g027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/d0345614d773/IJB-7-2-340-g028.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/79610943467c/IJB-7-2-340-g029.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/87581aee3f31/IJB-7-2-340-g030.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5912/8114098/566703b2da78/IJB-7-2-340-g031.jpg

相似文献

1
A Review on Design and Mechanical Properties of Additively Manufactured NiTi Implants for Orthopedic Applications.用于骨科应用的增材制造镍钛合金植入物的设计与力学性能综述
Int J Bioprint. 2021 Apr 15;7(2):340. doi: 10.18063/ijb.v7i2.340. eCollection 2021.
2
Topological design, permeability and mechanical behavior of additively manufactured functionally graded porous metallic biomaterials.增材制造功能梯度多孔金属生物材料的拓扑设计、渗透性和力学性能。
Acta Biomater. 2019 Jan 15;84:437-452. doi: 10.1016/j.actbio.2018.12.013. Epub 2018 Dec 8.
3
Fatigue behavior of As-built selective laser melted titanium scaffolds with sheet-based gyroid microarchitecture for bone tissue engineering.基于片层双曲蜂巢结构的增材制造钛支架疲劳行为及其在骨组织工程中的应用
Acta Biomater. 2019 Aug;94:610-626. doi: 10.1016/j.actbio.2019.05.046. Epub 2019 May 22.
4
In vitro evaluation of the biocompatibility and bioactivity of a SLM-fabricated NiTi alloy with superior tensile property.体外评价具有优异拉伸性能的 SLM 制造 NiTi 合金的生物相容性和生物活性。
J Mater Sci Mater Med. 2024 Aug 23;35(1):52. doi: 10.1007/s10856-024-06822-x.
5
Chemical Polishing of Additively Manufactured, Porous, Nickel-Titanium Skeletal Fixation Plates.增材制造多孔镍钛骨固定板的化学抛光
3D Print Addit Manuf. 2022 Aug 1;9(4):269-277. doi: 10.1089/3dp.2020.0209. Epub 2022 Aug 3.
6
Additively manufactured iron-manganese for biodegradable porous load-bearing bone scaffold applications.增材制造的铁锰合金用于可生物降解的多孔承重骨支架应用。
Acta Biomater. 2020 Feb;103:346-360. doi: 10.1016/j.actbio.2019.12.018. Epub 2019 Dec 18.
7
Mechanical and shape memory properties of porous NiTi alloys manufactured by selective laser melting.选择性激光熔化制造的多孔镍钛合金的力学和形状记忆性能
J Mech Behav Biomed Mater. 2017 Apr;68:224-231. doi: 10.1016/j.jmbbm.2017.01.047. Epub 2017 Jan 31.
8
A Review of Selective Laser Melted NiTi Shape Memory Alloy.选择性激光熔化镍钛形状记忆合金综述
Materials (Basel). 2018 Mar 29;11(4):519. doi: 10.3390/ma11040519.
9
Additive manufacturing of NiTi shape memory alloy and its industrial applications.镍钛形状记忆合金的增材制造及其工业应用。
Heliyon. 2023 Dec 6;10(1):e23369. doi: 10.1016/j.heliyon.2023.e23369. eCollection 2024 Jan 15.
10
Bionic mechanical design and 3D printing of novel porous Ti6Al4V implants for biomedical applications.用于生物医学应用的新型多孔 Ti6Al4V 植入物的仿生机械设计和 3D 打印。
J Zhejiang Univ Sci B. 2019;20(8):647-659. doi: 10.1631/jzus.B1800622.

引用本文的文献

1
Double-Layer Sol-Gel Modifications on Titanium Alloy Substrates-Physicochemical Properties Evaluation.钛合金基底上的双层溶胶-凝胶改性——物理化学性质评估
Materials (Basel). 2025 Aug 18;18(16):3857. doi: 10.3390/ma18163857.
2
Advancements in Nanotechnology for Spinal Surgery: Innovations in Spinal Fixation Devices for Enhanced Biomechanical Performance and Osteointegration.脊柱外科纳米技术的进展：用于增强生物力学性能和骨整合的脊柱固定装置的创新
Nanomaterials (Basel). 2025 Jul 10;15(14):1073. doi: 10.3390/nano15141073.
3
Nickel-titanium alloy porous scaffolds based on a dominant cellular structure manufactured by laser powder bed fusion have satisfactory osteogenic efficacy.

本文引用的文献

1
3D-printed HA15-loaded β-Tricalcium Phosphate/Poly (Lactic-co-glycolic acid) Bone Tissue Scaffold Promotes Bone Regeneration in Rabbit Radial Defects.3D打印载有HA15的β-磷酸三钙/聚（乳酸-乙醇酸）骨组织支架促进兔桡骨缺损的骨再生。
Int J Bioprint. 2021 Jan 20;7(1):317. doi: 10.18063/ijb.v7i1.317. eCollection 2021.
2
3D Printing Technologies in Metallic Implants: A Thematic Review on the Techniques and Procedures.金属植入物中的3D打印技术：技术与程序的专题综述
Int J Bioprint. 2020 Dec 9;7(1):306. doi: 10.18063/ijb.v7i1.306. eCollection 2021.
3
Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties.
基于激光粉末床熔融制造的具有主导细胞结构的镍钛合金多孔支架具有令人满意的成骨效果。
Mater Today Bio. 2024 Nov 15;29:101344. doi: 10.1016/j.mtbio.2024.101344. eCollection 2024 Dec.
4
Optimization Design and SLM Manufacturing of Porous Titanium Alloy Femoral Stem.多孔钛合金股骨柄的优化设计与选择性激光熔化制造
Materials (Basel). 2024 Oct 6;17(19):4896. doi: 10.3390/ma17194896.
5
The Effect of Ageing on Phase Transformations and Mechanical Behaviour in Ni-Rich NiTi Alloys.老化对富镍镍钛合金中相变及力学行为的影响。
Materials (Basel). 2024 May 17;17(10):2420. doi: 10.3390/ma17102420.
6
Orthopedic meta-implants.骨科金属植入物
APL Bioeng. 2024 Jan 19;8(1):010901. doi: 10.1063/5.0179908. eCollection 2024 Mar.
7
Composition Design and Tensile Properties of Additive Manufactured Low Density Hf-Nb-Ta-Ti-Zr High Entropy Alloys Based on Atomic Simulations.基于原子模拟的增材制造低密度铪-铌-钽-钛-锆高熵合金的成分设计与拉伸性能
Materials (Basel). 2023 May 29;16(11):4039. doi: 10.3390/ma16114039.
8
Medical high-entropy alloy: Outstanding mechanical properties and superb biological compatibility.医用高熵合金：卓越的力学性能与优异的生物相容性。
Front Bioeng Biotechnol. 2022 Aug 11;10:952536. doi: 10.3389/fbioe.2022.952536. eCollection 2022.
9
Current-Volt Biosensing "Cystatin C" on Carbon Nanowired Interdigitated Electrode Surface: A Clinical Marker Analysis for Bulged Aorta.碳纳米线交错电极表面的电流-电压生物传感“胱抑素C”：腹主动脉瘤的临床标志物分析
J Anal Methods Chem. 2022 May 23;2022:8160502. doi: 10.1155/2022/8160502. eCollection 2022.
10
Carbon Material Hybrid Construction on an Aptasensor for Monitoring Surgical Tumors.用于监测手术肿瘤的适配体传感器上的碳材料混合结构
J Anal Methods Chem. 2022 May 10;2022:9740784. doi: 10.1155/2022/9740784. eCollection 2022.
纳米改性钛植入材料：通往改善抗菌性能之路
Front Bioeng Biotechnol. 2020 Nov 23;8:576969. doi: 10.3389/fbioe.2020.576969. eCollection 2020.
4
Multi-Scale Surface Treatments of Titanium Implants for Rapid Osseointegration: A Review.用于快速骨整合的钛植入物的多尺度表面处理：综述
Nanomaterials (Basel). 2020 Jun 26;10(6):1244. doi: 10.3390/nano10061244.
5
Functionally graded titanium implants: Characteristic enhancement induced by combined severe plastic deformation.功能梯度钛植入物：联合强烈塑性变形诱导的特性增强。
PLoS One. 2019 Aug 23;14(8):e0221491. doi: 10.1371/journal.pone.0221491. eCollection 2019.
6
Review on titanium and titanium based alloys as biomaterials for orthopaedic applications.钛及钛基合金作为骨科应用生物材料的综述。
Mater Sci Eng C Mater Biol Appl. 2019 Sep;102:844-862. doi: 10.1016/j.msec.2019.04.064. Epub 2019 Apr 23.
7
Evaluation of the mechanical compatibility of additively manufactured porous Ti-25Ta alloy for load-bearing implant applications.评价增材制造多孔 Ti-25Ta 合金用于承重植入物应用的机械兼容性。
J Mech Behav Biomed Mater. 2019 Sep;97:149-158. doi: 10.1016/j.jmbbm.2019.05.019. Epub 2019 May 14.
8
Shape memory response of porous NiTi shape memory alloys fabricated by selective laser melting.选区激光熔化制备多孔 NiTi 形状记忆合金的形状记忆响应。
J Mater Sci Mater Med. 2018 Mar 21;29(4):40. doi: 10.1007/s10856-018-6044-6.
9
Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 over bio-functionalized highly porous titanium implant material.大孔率对生物功能化多孔钛植入材料表面 NIH/3T3 细胞黏附、增殖和向成骨细胞分化的影响。
J Biomed Mater Res B Appl Biomater. 2019 Jan;107(1):73-85. doi: 10.1002/jbm.b.34096. Epub 2018 Mar 8.
10
Metallic powder-bed based 3D printing of cellular scaffolds for orthopaedic implants: A state-of-the-art review on manufacturing, topological design, mechanical properties and biocompatibility.用于骨科植入物的基于金属粉末床的细胞支架3D打印：关于制造、拓扑设计、力学性能和生物相容性的最新综述
Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:1328-1343. doi: 10.1016/j.msec.2017.02.094. Epub 2017 Feb 24.