基于挤压式生物打印的甲状腺软骨支架支撑结构形成技术
The Technique of Thyroid Cartilage Scaffold Support Formation for Extrusion-Based Bioprinting.
作者信息
Arguchinskaya N V, Beketov E E, Kisel A A, Isaeva E V, Osidak E O, Domogatsky S P, Mikhailovsky N V, Sevryukov F E, Silantyeva N K, Agababyan T A, Ivanov S A, Shegay P V, Kaprin A D
机构信息
A. Tsyb MRRC - Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia.
Imtek Ltd., Moscow, Russia.
出版信息
Int J Bioprint. 2021 Apr 12;7(2):348. doi: 10.18063/ijb.v7i2.348. eCollection 2021.
During biofabrication, a tissue scaffold may require temporary support. The aim of this study was to develop an approach of human thyroid cartilage scaffold temporal support formation. The scaffold 3D-model was based on DICOM images. XY plane projections were used to form scaffold supporting part. To verify the technique, collagen hydrogel was chosen as the main scaffold component. Gelatin was applied for the supporting part. To test the applicability of the approach, a model of thyroid cartilage scaffold with the support was printed. The scaffold corresponded to a given model, although some discrepancy in geometry was observed during verification by computed tomography.
在生物制造过程中，组织支架可能需要临时支撑。本研究的目的是开发一种形成人甲状腺软骨支架临时支撑的方法。支架的三维模型基于DICOM图像。利用XY平面投影来形成支架支撑部分。为验证该技术，选择胶原水凝胶作为支架的主要成分。明胶用于支撑部分。为测试该方法的适用性，打印了带有支撑的甲状腺软骨支架模型。该支架与给定模型相符，不过在通过计算机断层扫描进行验证时，观察到了一些几何形状上的差异。
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