Department of Development and Regeneration, KU Leuven-University of Leuven, Leuven, Belgium.
KU Leuven Institute for Single Cell Omics (LISCO), Leuven, Belgium.
EMBO J. 2021 Jun 15;40(12):e108437. doi: 10.15252/embj.2021108437. Epub 2021 May 17.
Segregation of cells that form the embryo from those that produce the surrounding extra-embryonic tissues is critical for early mammalian development, but the regulatory layers governing these first cell fate decisions remain poorly understood. Recent work in The EMBO Journal identifies two chromatin regulators, Hdac3 and Dax1, that synergistically restrict the developmental potential of mouse embryonic stem cells and act as a lineage barrier to primitive endoderm formation.
胚胎细胞与产生周围胚胎外组织的细胞的分离对于早期哺乳动物发育至关重要，但调控这些最初细胞命运决定的调控层仍知之甚少。最近在《欧洲分子生物学组织杂志》上的一项工作确定了两个染色质调节剂，Hdac3 和 Dax1，它们协同限制了小鼠胚胎干细胞的发育潜力，并作为原始内胚层形成的谱系屏障。
