保持命运：染色质调控因子如何保障胚胎干细胞的身份。
Keep the fate: how chromatin regulators safeguard embryonic stem cell identity.
机构信息
Department of Development and Regeneration, KU Leuven-University of Leuven, Leuven, Belgium.
KU Leuven Institute for Single Cell Omics (LISCO), Leuven, Belgium.
出版信息
EMBO J. 2021 Jun 15;40(12):e108437. doi: 10.15252/embj.2021108437. Epub 2021 May 17.
Abstract
Segregation of cells that form the embryo from those that produce the surrounding extra-embryonic tissues is critical for early mammalian development, but the regulatory layers governing these first cell fate decisions remain poorly understood. Recent work in The EMBO Journal identifies two chromatin regulators, Hdac3 and Dax1, that synergistically restrict the developmental potential of mouse embryonic stem cells and act as a lineage barrier to primitive endoderm formation.
摘要
胚胎细胞与产生周围胚胎外组织的细胞的分离对于早期哺乳动物发育至关重要，但调控这些最初细胞命运决定的调控层仍知之甚少。最近在《欧洲分子生物学组织杂志》上的一项工作确定了两个染色质调节剂，Hdac3 和 Dax1，它们协同限制了小鼠胚胎干细胞的发育潜力，并作为原始内胚层形成的谱系屏障。
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本文引用的文献
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Cooperation between HDAC3 and DAX1 mediates lineage restriction of embryonic stem cells.HDAC3 和 DAX1 之间的合作介导胚胎干细胞的谱系限制。
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Chromatin accessibility and the regulatory epigenome.染色质可及性和调控表观基因组。
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PDGFRα Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors.胚胎干细胞培养中的血小板衍生生长因子受体α（PDGFRα）细胞代表着床前原始内胚层前体的体外等效物。
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The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.同源结构域蛋白Nanog是维持小鼠上胚层细胞和胚胎干细胞多能性所必需的。
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