Agrawal Shivankar, Samanta Sreeparna, Deshmukh Sunil Kumar
Indian Council of Medical Research, IJMR Unit, Delhi, India.
TERI-Deakin Nano Biotechnology Centre, Biotechnology and Management of Bioresources Division, The Energy and Resources Institute, New Delhi, India.
Biotechnol Appl Biochem. 2022 Jun;69(3):1159-1165. doi: 10.1002/bab.2192. Epub 2021 May 25.
Diabetes mellitus is one of the most common systemic diseases in the world, and it occurs when the body becomes resistant to insulin or does not make enough insulin. As described by the World Health Organization, diabetes mellitus of all types has exponentially grown in the past decades across the globe and it is estimated to be 629 million by 2045. Despite this alarming prevalence of diabetes mellitus, there is still the lack of harmless preventive medicines. Natural products and compounds obtained from plants, fungi, bacteria, and other living organisms have been used for many decades in folklore medicine to prepare a varied range of natural formulations to treat multiple diseases and illnesses. Endophytic fungi reside inside the plant while causing no harm to the host plant and are relatively less explored as the primary source for the bioactive metabolites such as anticancer, antioxidant, antimicrobial, antidiabetic, and industrial enzymes. This mini-review summarizes the potential of compounds and extracts from endophytic fungi against diabetes mellitus. Not much research has been dedicated in-depth understanding of the role of extracts of endophytic fungi and their effect on diabetes mellitus. Therefore, this article will focus on recent work and warrant further commentaries on the published articles.
糖尿病是世界上最常见的全身性疾病之一，当身体对胰岛素产生抗性或胰岛素分泌不足时就会发生。正如世界卫生组织所描述的那样，在过去几十年中，全球所有类型的糖尿病呈指数级增长，预计到2045年将达到6.29亿例。尽管糖尿病的患病率令人担忧，但仍然缺乏无害的预防药物。从植物、真菌、细菌和其他生物体中获得的天然产物和化合物在民间医学中已经使用了几十年，用于制备各种天然制剂来治疗多种疾病。内生真菌寄生于植物体内而对宿主植物无害，作为抗癌、抗氧化、抗菌、抗糖尿病和工业酶等生物活性代谢产物的主要来源，其研究相对较少。本综述总结了内生真菌的化合物和提取物抗糖尿病的潜力。目前对内生真菌提取物的作用及其对糖尿病的影响尚未进行深入研究。因此，本文将重点关注近期的研究工作，并对已发表的文章进行进一步评论。
