Kazatchkine M, Sultan Y, Caen J P, Bariety J
Br Med J. 1976 Sep 11;2(6036):612-5. doi: 10.1136/bmj.2.6036.612.
Increased concentrations of factor VIII-related antigen (VIIIRA), factor VIII-procoagulant activity (VIIC), and decreased factor VII-von Willebrand activity (VIIIVWF) were found in the plasma of patients with chronic renal failure (CRF). This functional abnormality of the factor VII protein may partly explain the prolonged bleeding time commonly found in CRF. It was not improved by dialysis, but it was no longer found in patients with normally functioning grafted kidneys after the sixth month after transplantation. VIIIVWF levels remained decreased when compared with VIIIRA or VIIIC in transplanted patients undergoing acute reversible rejection soon after transplantation. Yet, not only VIIIC and VIIIRA but also VIIIVWF were greatly increased in patients with hyperacute irreversible rejection. Possibly a high VIIIVWF level in these patients is a thrombogenic factor.
在慢性肾衰竭（CRF）患者的血浆中发现，VIII因子相关抗原（VIIIRA）、VIII因子促凝血活性（VIIC）浓度升高，而VII因子-血管性血友病因子活性（VIIIVWF）降低。VII因子蛋白的这种功能异常可能部分解释了CRF患者常见的出血时间延长现象。透析并不能改善这种情况，但移植后六个月后肾功能正常的移植肾患者不再出现这种情况。移植后不久发生急性可逆性排斥反应的患者，其VIIIVWF水平与VIIIRA或VIIC相比仍降低。然而，在发生超急性不可逆排斥反应的患者中，不仅VIIC和VIIIRA，而且VIIIVWF都大幅升高。这些患者中较高的VIIIVWF水平可能是一个促血栓形成因素。
