2 型糖尿病和重度抑郁症的共同代谢和神经免疫机制。
Shared metabolic and neuroimmune mechanisms underlying Type 2 Diabetes Mellitus and Major Depressive Disorder.
机构信息
Laboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), PE, Brazil; Postgraduate Program in Biosciences and Biotechnology for Health (PPGBBS), Oswaldo Cruz Foundation (FIOCRUZ-PE)/Aggeu Magalhães Institute (IAM), Recife, PE, Brazil; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Recife, PE, Brazil.
Laboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), PE, Brazil; Postgraduate Program in Biological Sciences (PPGCB), Federal University of Pernambuco (UFPE), Brazil.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110351. doi: 10.1016/j.pnpbp.2021.110351. Epub 2021 May 14.
Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease with symptoms that go beyond the domain of glucose metabolism. In fact, research has shown that T2DM is accompanied by neurodegeneration and neuroinflammation. Interestingly, Major Depressive Disorder (MDD), a mood disorder characterized mainly by depressed mood and anhedonia is a key feature of T2DM. A body of evidence demonstrates that there are many shared neuroimmune mechanisms underlying the pathophysiology of T2DM and MDD. Therefore, here we review the state-of-art regarding the underlying factors common to both T2DM and MDD. Furthermore, we briefly discuss how depressive symptoms in diabetic patients could be tackled by using novel therapeutic approaches uncovered by these shared mechanisms. Understanding the comorbidity of depression in diabetic patients is essential to fully address T2DM pathophysiology and treatment.
2 型糖尿病（T2DM）是一种慢性代谢性疾病，其症状不仅涉及葡萄糖代谢。事实上，研究表明，T2DM 伴随着神经退行性变和神经炎症。有趣的是，以情绪低落和快感缺失为主要特征的心境障碍——重度抑郁症（MDD）是 T2DM 的一个关键特征。大量证据表明，T2DM 和 MDD 的病理生理学存在许多共同的神经免疫机制。因此，在这里我们回顾了 T2DM 和 MDD 共有的潜在因素的最新研究进展。此外，我们还简要讨论了如何通过利用这些共同机制发现的新治疗方法来解决糖尿病患者的抑郁症状。了解糖尿病患者抑郁共病对于充分解决 T2DM 病理生理学和治疗至关重要。
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