Khan Muhammad Zubair, Patel Kirtenkumar, Patel Krunalkumar A, Doshi Rajkumar, Shah Vraj, Adalja Devina, Waqar Zainulabedin, Franklin Sona, Gupta Neelesh, Gul Muhammad Hamdan, Jesani Shruti, Kutalek Steven, Figueredo Vincent
Department of Internal Medicine, St. Mary Medical Center, Langhorne, PA 19047, United States.
Division of Cardiology, North Shore University Hospital, Manhasset, NY 11030, United States.
World J Clin Cases. 2021 May 16;9(14):3252-3264. doi: 10.12998/wjcc.v9.i14.3252.
Studies have suggested that atrial fibrillation (AF) in patients with rheumatic diseases (RD) may be due to inflammation.
To determine the highest association of AF among hospitalized RD patients and to determine morbidity and mortality associated with AF in hospitalized patients with RD.
The National inpatient sample database from October 2015 to December 2017 was analyzed to identify hospitalized patients with RD with and without AF. A subgroup analysis was performed comparing outcomes of AF among different RD.
The prevalence of AF was 23.9% among all patients with RD ( = 3949203). Among the RD subgroup, the prevalence of AF was highest in polymyalgia rheumatica (33.2%), gout (30.2%), and pseudogout (27.1%). After adjusting for comorbidities, the odds of having AF were increased with gout (1.25), vasculitis (1.19), polymyalgia rheumatica (1.15), dermatopolymyositis (1.14), psoriatic arthropathy (1.12), lupus (1.09), rheumatoid arthritis (1.05) and pseudogout (1.04). In contrast, enteropathic arthropathy (0.44), scleroderma (0.96), ankylosing spondylitis (0.96), and Sjorgen's syndrome (0.94) had a decreased association of AF. The mortality, length of stay, and hospitalization costs were higher in patients with RD having AF without AF. Among the RD subgroup, the highest mortality was found with scleroderma (4.8%), followed by vasculitis (4%) and dermatopolymyositis (3.5%).
A highest association of AF was found with gout followed by vasculitis, and polymyalgia rheumatica when compared to other RD. Mortality was two-fold higher in patients with RD with AF.
研究表明，风湿性疾病（RD）患者的心房颤动（AF）可能与炎症有关。
确定住院RD患者中AF的最高关联度，并确定住院RD患者中与AF相关的发病率和死亡率。
分析2015年10月至2017年12月的国家住院患者样本数据库，以识别患有和未患有AF的住院RD患者。进行亚组分析，比较不同RD中AF的结局。
所有RD患者（n = 3949203）中AF的患病率为23.9%。在RD亚组中，AF患病率在风湿性多肌痛（33.2%）、痛风（30.2%）和假性痛风（27.1%）中最高。在调整合并症后，痛风（1.25）、血管炎（1.19）、风湿性多肌痛（1.15）、皮肌炎（1.14）、银屑病关节炎（1.12）、狼疮（1.09）、类风湿性关节炎（1.05）和假性痛风（1.04）患者发生AF的几率增加。相比之下，肠病性关节炎（0.44）、硬皮病（0.96）、强直性脊柱炎（0.96）和干燥综合征（0.94）与AF的关联度降低。患有AF的RD患者的死亡率、住院时间和住院费用均高于未患有AF的患者。在RD亚组中，硬皮病的死亡率最高（4.8%），其次是血管炎（4%）和皮肌炎（3.5%）。
与其他RD相比，AF与痛风的关联度最高，其次是血管炎和风湿性多肌痛。患有AF的RD患者的死亡率高出两倍。
