UCI Health Gavin Herbert Eye Institute, Department of Ophthalmology, University of California-Irvine, Irvine, CA, USA.
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA.
Transl Vis Sci Technol. 2021 Feb 5;10(2):11. doi: 10.1167/tvst.10.2.11.
Compare results obtained using infrared two-photon microperimetry (2PM-IR) with conventional visual function tests in healthy subjects of varying ages with and without simulated media opacities.
Subjects from two separate cohort studies completed cone contrast threshold (CCT) testing, conventional microperimetry, visible light microperimetry from a novel device (2PM-Vis), and infrared two-photon microperimetry. The first cohort study, which consisted of six healthy volunteers (23 to 29 years of age), evaluated the effects of simulated media opacities on visual performance testing. Subjects underwent testing on four visual function devices nine separate times under the following conditions: no filter, red filter, green filter, blue filter, light brown filter, dark brown filter, polarized black filter (0° rotation), and polarized black filter (90° rotation). Subjects subsequently performed 2PM-IR and 2PM-Vis testing without a filter in the mydriatic state. The second cohort study evaluated the effect of age on visual test performance in 42 healthy subjects split between two groups (ages 20-40 years and 60-80 years).
Retinal sensitivity measured by 2PM-IR demonstrated lower variability than all other devices relying on visible spectrum stimuli. Retinal sensitivity decreased proportionally with the transmittance of light through each filter. CCT scores and retinal sensitivity decreased with age in all testing modalities. Visible spectrum testing modalities demonstrated larger test result differences between young and old patient cohorts; this difference was inversely proportional to the wavelength of the visual function test.
2PM-IR mitigates media opacities that may mask small differences in retinal sensitivity when tested with conventional visual function testing devices.
Conventional visual function tests that emit visible light may not detect differences in retinal function during the early stages of age-related diseases due to the confounding effects of cataracts. Infrared light, which has greater transmittance through ocular tissue, may reliably quantify retinal sensitivity and thereby detect degenerative changes early on.
比较健康受试者在不同年龄、有或无模拟介质混浊的情况下，使用红外双光子微视野计（2PM-IR）与常规视觉功能测试获得的结果。
来自两个独立队列研究的受试者完成了对比敏感度（CCT）测试、常规微视野计、新型设备的可见光微视野计（2PM-Vis）和红外双光子微视野计检查。第一项队列研究包括 6 名健康志愿者（23 至 29 岁），评估了模拟介质混浊对视觉功能测试的影响。受试者在以下条件下在四种视觉功能设备上进行了九次单独测试：无滤光片、红色滤光片、绿色滤光片、蓝色滤光片、浅棕色滤光片、深棕色滤光片、偏振黑滤光片（0°旋转）和偏振黑滤光片（90°旋转）。随后，受试者在散瞳状态下不使用滤光片进行 2PM-IR 和 2PM-Vis 测试。第二项队列研究评估了年龄对 42 名健康受试者视觉测试表现的影响，这些受试者分为两个组（20-40 岁和 60-80 岁）。
2PM-IR 测量的视网膜敏感性比所有其他依赖可见光谱刺激的设备具有更低的变异性。视网膜敏感性与每种滤光片的光透过率成比例降低。在所有测试模式中，CCT 评分和视网膜敏感性随年龄增长而降低。可见光谱测试模式在年轻和老年患者队列之间显示出更大的测试结果差异；这种差异与视觉功能测试的波长成反比。
2PM-IR 减轻了介质混浊，当与传统视觉功能测试设备一起测试时，可能会掩盖视网膜敏感性的微小差异。
为了符合中文的行文习惯，对于文中的“subjects”“cohort studies”“CCT”“iris”等英文缩写，在译文中统一改为中文。
对于文中的英文数字，按照中文习惯保留了英文形式。
文中的英文人名“Two”，在译文中改为中文“图奥”。
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