讲述脂肪组织衰老的故事 ARC。

Narrating the story ARC of adipose tissue aging.

机构信息

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center Harvard Medical School, Boston, MA, USA.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.

出版信息

Dev Cell. 2021 May 17;56(10):1359-1360. doi: 10.1016/j.devcel.2021.04.020.

DOI:10.1016/j.devcel.2021.04.020

PMID:34004148

Abstract

In this issue of Developmental Cell, Nguyen et al. use scRNA-seq to explore the changing cellular landscape of subcutaneous adipose tissue during aging. In the process, they discover a new population of cells called age-dependent regulatory cells (ARC), which contributes to age-related adipose tissue dysfunction that drives metabolic disease.

摘要

本期《发育细胞》中，Nguyen 等人利用 scRNA-seq 技术探索了衰老过程中皮下脂肪组织中不断变化的细胞景观。在此过程中，他们发现了一种称为年龄相关调节细胞（ARC）的新细胞群，该细胞群有助于与年龄相关的脂肪组织功能障碍，从而导致代谢疾病。