Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Alzheimers Dement. 2023 Jan;19(1):44-55. doi: 10.1002/alz.12626. Epub 2022 Mar 9.
We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle.
Participants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans.
Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age-standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia.
The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.
我们评估了以自给自足生活方式为主的本土提斯曼人和莫斯特恩人患痴呆症和轻度认知障碍（MCI）的患病率。
对来自基于人群的样本中年龄≥60 岁的参与者（n=623）进行了评估，使用改良简易精神状态检查、知情者访谈、纵向认知测试和脑计算机断层扫描（CT）的改编版本。
提斯曼人中出现了 5 例痴呆症（n=435；粗患病率=1.2%，95%置信区间[CI]：0.4，2.7）；莫斯特恩人中出现了 1 例（n=169；粗患病率=0.6%，95%CI：0.0，3.2），均为年龄≥80 岁。提斯曼人的年龄标准化 MCI 患病率为 7.7%（95%CI：5.2，10.3），莫斯特恩人为 9.8%（95%CI：4.9，14.6）。认知障碍与视空间障碍、帕金森症状和基底节血管钙化有关。
该队列的痴呆症患病率处于世界最低水平之列。广泛的颅内内侧动脉钙化提示存在一种以前未被认识到的、非阿尔茨海默病（AD）痴呆表型。
