School of Biological Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia; Nanotechnology & Catalysis Research Centre (NANOCAT), Institute for Advanced Studies, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Nanotechnology & Catalysis Research Centre (NANOCAT), Institute for Advanced Studies, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Chemosphere. 2021 Oct;281:130739. doi: 10.1016/j.chemosphere.2021.130739. Epub 2021 May 13.
Recent advances in the field of nanotechnology contributed to the increasing use of nanomaterials in the engineering, health and biological sectors. Graphene oxide (GO) has great potentials as it could be fine-tuned to be adapted into various applications, especially in the electrical, electronic, industrial and clinical fields. One of the important applications of GO is its use as an antibacterial material due to its promising activity against a broad range of bacteria. However, our understanding of the mechanism of action of GO towards bacteria is still lacking and is often less described. Therefore, a comprehensive overview of bactericidal mechanistic actions of GO and the roles of physicochemical factors including size, aggregation, functionalization and adsorption behavior contributing to its antibacterial activities are described in this review. As the use of GO is expected to increase exponentially in the health sector, the cytotoxicity of GO among the cell lines is also discussed. Thus, this review emphasizes the physicochemical characteristics of GO that can be tailored for optimal antibacterial properties that is of importance to the health industry.
近年来，纳米技术领域的进展促进了纳米材料在工程、健康和生物领域的应用日益增多。氧化石墨烯（GO）具有很大的潜力，因为它可以进行微调以适应各种应用，特别是在电气、电子、工业和临床领域。GO 的一个重要应用是将其用作抗菌材料，因为它对广泛的细菌具有有前景的活性。然而，我们对 GO 对细菌的作用机制的理解仍然缺乏，而且通常描述得较少。因此，本综述描述了 GO 的杀菌机制作用以及包括尺寸、聚集、功能化和吸附行为在内的物理化学因素在其抗菌活性中的作用。由于预计 GO 在医疗保健领域的使用将呈指数级增长，因此本综述还讨论了 GO 在细胞系中的细胞毒性。因此，本综述强调了可以针对最佳抗菌性能进行定制的 GO 的物理化学特性，这对健康产业非常重要。
