Sargent E V, Kirk G D
Corporate Safety and Industrial Hygiene, Merck and Co., Inc., Rahway, NJ 07065.
Am Ind Hyg Assoc J. 1988 Jun;49(6):309-13. doi: 10.1080/15298668891379792.
In the course of employment, workers in the pharmaceutical industry are exposed to compounds which are designed to produce pharmacological effects. For the most part, exposure occurs in the handling of finely divided solids. Data from laboratory animal studies and clinical trials can be extrapolated to predict possible effects of exposure in the workplace. To that end a procedure for establishing workplace exposure control limits (ECLs) for pharmaceutical products is presented. Workplace exposure limits are given for 32 human health drugs.
在制药行业的工作过程中，工人会接触到旨在产生药理作用的化合物。在大多数情况下，接触发生在处理细分固体时。来自实验室动物研究和临床试验的数据可以外推，以预测工作场所接触可能产生的影响。为此，本文提出了一种确定药品工作场所接触控制限值（ECL）的程序。给出了32种人类健康药物的工作场所接触限值。
