Li Fan, Huo Yiming, Ma Lihua, Tang Guangxian
Department of Ophthalmology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050000, China.
Hebei Medical University, Shijiazhuang, Hebei 050000, China.
J Ophthalmol. 2021 Apr 9;2021:5574950. doi: 10.1155/2021/5574950. eCollection 2021.
To evaluate the differences in macular choroidal thickness and volume between patients with primary open-angle glaucoma (POAG) and healthy controls to assess the correlation between macular choroidal thickness and visual field mean defect (MD).
Case-control study. A total of 101 patients (101 eyes) with POAG who were hospitalized in our hospital and 102 healthy subjects (102 eyes) matched by age, sex, and axial length were consecutively selected as the POAG group and the control group, respectively. The macular choroidal thickness and volume in nine regions were measured in all subjects by enhanced-depth imaging optical coherence tomography (EDI-OCT).
The mean thicknesses of the choroid in the macular area in the POAG group and healthy group were 207.97 ± 62.83 m and 208.24 ± 47.97 m, and the mean volumes were 0.63 ± 0.19 m and 0.64 ± 0.14 m. There were no significant differences in macular choroidal thickness, volumes of various macular regions, or mean choroidal thickness or volume between the POAG and healthy groups (all > 0.05). The macular choroidal thickness of various macular regions was not correlated with visual field MD in the POAG group (all > 0.05).
The macular choroidal thicknesses and volumes in POAG patients were not significantly different from those in healthy individuals. The macular choroidal thickness was not correlated with MD in POAG patients. Therefore, macular choroidal thickness is not an appropriate parameter to evaluate damage caused by POAG, and the role of the macular choroid thickness in POAG needs to be further investigated.
评估原发性开角型青光眼（POAG）患者与健康对照者黄斑脉络膜厚度和体积的差异，以评估黄斑脉络膜厚度与视野平均缺损（MD）之间的相关性。
病例对照研究。连续选取我院收治的101例POAG患者（101只眼）及102名年龄、性别和眼轴长度匹配的健康受试者（102只眼），分别作为POAG组和对照组。采用增强深度成像光学相干断层扫描（EDI-OCT）测量所有受试者九个区域的黄斑脉络膜厚度和体积。
POAG组和健康组黄斑区脉络膜平均厚度分别为207.97±62.83μm和208.24±47.97μm，平均体积分别为0.63±0.19mm³和0.64±0.14mm³。POAG组与健康组在黄斑脉络膜厚度、各黄斑区域体积、脉络膜平均厚度或体积方面均无显著差异（均P>0.05）。POAG组各黄斑区域的黄斑脉络膜厚度与视野MD均无相关性（均P>0.05）。
POAG患者的黄斑脉络膜厚度和体积与健康个体无显著差异。POAG患者的黄斑脉络膜厚度与MD无相关性。因此，黄斑脉络膜厚度不是评估POAG所致损害的合适参数，黄斑脉络膜厚度在POAG中的作用有待进一步研究。
