Li Fan, Huo Yiming, Ma Lihua, Zhang Qing, Zhang Hengli, Yan Xiaowei, Geng Yulei, Tang Guangxian
Department of Ophthalmology, Shijiazhuang People's Hospital, 365 Jianhua Road, Shijiazhuang, Hebei, China.
Department of Ophthalmology, Shijiazhuang Aier Eye Hospital, 252 Zhonghua Road, Shijiazhuang, Hebei, China.
J Ophthalmol. 2021 Nov 16;2021:3897952. doi: 10.1155/2021/3897952. eCollection 2021.
To evaluate the differences in macular choroidal thickness and volume among patients with pseudoexfoliative glaucoma (PXG), patients with primary open-angle glaucoma (POAG), and controls.
A total of 50 PXG patients (50 eyes) and 56 POAG patients (56 eyes) were selected as the PXG group and the POAG group, respectively, in this case-control study. A total of 54 age-, gender-, IOP-, and axial length-matched healthy individuals (54 eyes) were selected as the control group. Enhanced-depth imaging-optical coherence tomography (EDI-OCT) was used to measure and analyze the choroidal thicknesses and volumes in 9 macular regions of all subjects.
The choroidal thicknesses in the central subfield (CSM), temporal inner macula (TIM), inferior inner macula (IIM), and temporal outer macula (TOM) and the mean macular choroidal thickness were significantly thinner in the PXG group than in the control group (all < 0.05). The choroidal volumes in the TIM, IIM, and TOM and the mean macular choroidal volume were significantly smaller in the PXG group than in the control group (all < 0.05). The choroidal thicknesses in the CSM and IIM and the mean macular choroidal thickness were significantly thinner in the PXG group than in the POAG group (all < 0.05). The choroidal volumes in the IIM and TOM and the mean macular choroidal volume were significantly smaller in the PXG group than in the POAG group (all < 0.05). Multivariable linear regression analysis showed that the mean macular choroidal thickness was significantly thinner in association with older subjects and longer axial length eyes. There was no association between the macular choroidal thickness of various macular regions and visual field mean defect (MD) in groups PXG and POAG (all > 0.05).
The macular choroidal thicknesses and volumes (inferior and temporal) in PXG patients were thinner and smaller than those in POAG patients and healthy individuals. The role of choroidal thickness changes in the course of PXG remains unclear. A future prospective study is needed to better define these changes in PXG patients.
评估假性剥脱性青光眼（PXG）患者、原发性开角型青光眼（POAG）患者和对照组之间黄斑脉络膜厚度和体积的差异。
在这项病例对照研究中，分别选取50例PXG患者（50只眼）和56例POAG患者（56只眼）作为PXG组和POAG组。选取54例年龄、性别、眼压和眼轴长度匹配的健康个体（54只眼）作为对照组。采用增强深度成像光学相干断层扫描（EDI-OCT）测量和分析所有受试者9个黄斑区域的脉络膜厚度和体积。
PXG组中心子野（CSM）、颞侧黄斑内侧（TIM）、下方黄斑内侧（IIM）和颞侧黄斑外侧（TOM）的脉络膜厚度以及平均黄斑脉络膜厚度均显著低于对照组（均P<0.05）。PXG组TIM、IIM和TOM的脉络膜体积以及平均黄斑脉络膜体积均显著小于对照组（均P<0.05）。PXG组CSM和IIM的脉络膜厚度以及平均黄斑脉络膜厚度均显著低于POAG组（均P<0.05）。PXG组IIM和TOM的脉络膜体积以及平均黄斑脉络膜体积均显著小于POAG组（均P<0.05）。多变量线性回归分析显示，平均黄斑脉络膜厚度与年龄较大的受试者和眼轴较长的眼睛显著变薄有关。PXG组和POAG组各黄斑区域的黄斑脉络膜厚度与视野平均缺损（MD）之间均无关联（均P>0.05）。
PXG患者的黄斑脉络膜厚度和体积（下方和颞侧）比POAG患者和健康个体更薄、更小。脉络膜厚度变化在PXG病程中的作用尚不清楚。未来需要进行前瞻性研究，以更好地明确PXG患者的这些变化。
