Institute of Materials Engineering, College of Engineering and Applied Sciences, Nanjing University, Jiangsu, 210093, China.
Nantong Vocational University, Nantong, 226019, China.
Macromol Biosci. 2021 Aug;21(8):e2100092. doi: 10.1002/mabi.202100092. Epub 2021 May 18.
Hypoxia as one of the most prominent features in tumors, has presented negative effects on tumor therapies including photodynamic therapy, radiotherapy, and chemotherapies, leading to the tumor regeneration and metastasis. Recently, nanomedicines have been proposed to handle the hypoxia dilemma. Some nanomedicines alleviated hypoxia to enhance the therapeutic effect, others used hypoxia-sensitive substances to treat tumor. Among them, macromolecular nanomaterials-based nanomedicine has attracted increased research interest. However, the complicated tumor microenvironment disturbs the practical application of macromolecular nanomaterials to deal with hypoxia. This review highlights the influence of hypoxia on tumor therapy and some new strategies of using macromolecular nanomaterials to overcome hypoxia for effective tumor therapy.
缺氧作为肿瘤中最显著的特征之一，对包括光动力疗法、放射疗法和化学疗法在内的肿瘤疗法产生了负面影响，导致肿瘤再生和转移。最近，纳米医学被提出用于解决缺氧难题。一些纳米药物缓解了缺氧以增强治疗效果，另一些则使用了对缺氧敏感的物质来治疗肿瘤。其中，基于高分子纳米材料的纳米药物引起了越来越多的研究兴趣。然而，复杂的肿瘤微环境干扰了高分子纳米材料在应对缺氧方面的实际应用。本文综述了缺氧对肿瘤治疗的影响，以及利用高分子纳米材料克服缺氧以实现有效肿瘤治疗的一些新策略。
