Luo Xingyu, Cao Jian, Yu Jianming, Dai Dongqing, Jiang Wei, Feng Yahui, Hu Yong
College of Engineering and Applied Sciences, MOE Key Laboratory of High Performance Polymer Materials & Technology, Nanjing University, Nanjing, China.
Nanjing Customs District Industrial Products Inspection Center, Nanjing, China.
Front Bioeng Biotechnol. 2022 May 12;10:885105. doi: 10.3389/fbioe.2022.885105. eCollection 2022.
Acidosis and hypoxia of tumor remain a great challenge for cancer therapy. Herein, we developed Hb-LOX-DOX-ZIF8@platelet membrane nanoparticles (H-L-D-Z@PM NPs) to address this problem. Lactate oxidase (LOX) could deplete intratumoral lactate adequately and amplify oxidative stress efficiently. In the meantime, hemoglobin (Hb) was intended to deliver oxygen, relieve hypoxia, and boost the catalytic activity of LOX. The coated PM bestowed active tumor-targeting ability and good biocompatibility to these nanoparticles. Moreover, the encapsulation of zeolitic imidazolate framework-8 (ZIF8) offered the acid response capacity to nanoparticles. With the synergism of chemotherapy drug doxorubicin (DOX), these H-L-D-Z@PM NPs appeared to have excellent antitumor competence. Collectively, this study offered a new strategy for enhancing tumor chemotherapy by regulating acidosis and relieving hypoxia.
肿瘤的酸中毒和缺氧仍然是癌症治疗面临的巨大挑战。在此，我们开发了血红蛋白-乳酸氧化酶-阿霉素-沸石咪唑酯骨架材料8@血小板膜纳米颗粒（H-L-D-Z@PM NPs）来解决这一问题。乳酸氧化酶（LOX）能够充分消耗肿瘤内的乳酸，并有效放大氧化应激。同时，血红蛋白（Hb）旨在输送氧气、缓解缺氧并增强LOX的催化活性。包覆的血小板膜赋予这些纳米颗粒主动肿瘤靶向能力和良好的生物相容性。此外，沸石咪唑酯骨架材料8（ZIF8）的包裹赋予纳米颗粒酸响应能力。在化疗药物阿霉素（DOX）的协同作用下，这些H-L-D-Z@PM NPs似乎具有出色的抗肿瘤能力。总的来说，本研究提供了一种通过调节酸中毒和缓解缺氧来增强肿瘤化疗的新策略。
