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过氧化物酶模拟纳米酶在癌症光疗中的应用：进展与展望。

Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives.

机构信息

Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.

Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.

出版信息

Biomolecules. 2021 Jul 11;11(7):1015. doi: 10.3390/biom11071015.

DOI:10.3390/biom11071015
PMID:34356639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8301984/
Abstract

Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical applications. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (HO) to oxygen (O) and peroxidase (POD) mimetic nanozymes converts endogenous HO to water (HO) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.

摘要

纳米材料介导的癌症治疗是一个快速发展的领域，并已应用于潜在的临床应用中。然而，大多数有效的治疗方法，如光动力疗法 (PDT) 和放射疗法 (RT)，强烈依赖于氧气，这阻碍了它们的实际应用。后来，开发了几种策略来克服肿瘤缺氧，例如氧载体纳米材料和氧气产生纳米材料。在这些策略中，纳米酶上的氧物种生成，特别是过氧化氢酶 (CAT) 模拟纳米酶，将内源性过氧化氢 (HO) 转化为氧气 (O)，而过氧化物酶 (POD) 模拟纳米酶将内源性 HO 转化为水 (HO) 和活性氧物种 (ROS) 在缺氧的肿瘤微环境中是一种很有前途的方法。本综述详细考察了 POD 模拟纳米酶在有效的氧依赖型癌症光疗中的过去、现在和未来前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/8a47c7eae224/biomolecules-11-01015-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/d438c51d6cf0/biomolecules-11-01015-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/79b66fa64596/biomolecules-11-01015-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/888610ccb751/biomolecules-11-01015-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/0ab668e55004/biomolecules-11-01015-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/d1e233bf1d09/biomolecules-11-01015-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/60c0aae686c4/biomolecules-11-01015-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/7df1812445c5/biomolecules-11-01015-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/8a47c7eae224/biomolecules-11-01015-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/d438c51d6cf0/biomolecules-11-01015-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/79b66fa64596/biomolecules-11-01015-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/888610ccb751/biomolecules-11-01015-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/0ab668e55004/biomolecules-11-01015-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/d1e233bf1d09/biomolecules-11-01015-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/60c0aae686c4/biomolecules-11-01015-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/7df1812445c5/biomolecules-11-01015-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b7e/8301984/8a47c7eae224/biomolecules-11-01015-g007.jpg

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本文引用的文献

[1]
A cobalt-doped iron oxide nanozyme as a highly active peroxidase for renal tumor catalytic therapy.

RSC Adv. 2019-6-17

[2]
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RSC Adv. 2019-12-23

[3]
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Natl Sci Rev. 2020-7-8

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Recent advances in near infrared light responsive multi-functional nanostructures for phototheranostic applications.

Biomater Sci. 2021-8-21

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Biodegradable and Peroxidase-Mimetic Boron Oxynitride Nanozyme for Breast Cancer Therapy.

Adv Sci (Weinh). 2021-8

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Near-Infrared Light Enhanced Peroxidase-Like Activity of PEGylated Palladium Nanozyme for Highly Efficient Biofilm Eradication.

J Biomed Nanotechnol. 2021-6-1

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Nanomicro Lett. 2020-10-27

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Single NIR Laser-Activated Multifunctional Nanoparticles for Cascaded Photothermal and Oxygen-Independent Photodynamic Therapy.

Nanomicro Lett. 2019-8-19

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Ultrasmall Alloy Nanozyme for Ultrasound- and Near-Infrared Light-Promoted Tumor Ablation.

ACS Nano. 2021-4-27

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Tailoring photosensitive ROS for advanced photodynamic therapy.

Exp Mol Med. 2021-4

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