the National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330088, P.R. China.
College of Mechanical & Electronic Engineering, Nanchang University, Nanchang, Jiangxi 330088, P.R. China.
ACS Appl Mater Interfaces. 2021 Jun 2;13(21):24453-24462. doi: 10.1021/acsami.1c03134. Epub 2021 May 19.
A dual-response (near-infrared, alternating magnetic field) multifunctional nanoplatform was developed based on urokinase plasminogen activators (uPA)-loaded metal-organic-framework (MOF)-derived carbon nanomaterials (referred to uPA@CFs below) for thrombolytic therapy. uPA loaded in mesoporous CFs could be released under the action of near-infrared (NIR)-mediated photothermy to achieve superficial thrombolysis. More importantly, with the assistance of alternating magnetic field (AMF), this system could also precisely heat the thrombosis in the deep tissue area. Quantitative experiments proved that the thrombolytic efficiency of this dual-response system at deep venous thrombosis was nearly 6 times than that of NIR alone. This is the first application that MOF-derived carbon nanomaterials in the field of targeted thrombolysis. To our delight, the MOF-derived carbon nanomaterials (CFs) not only maintained the drug-carrying capacity, but also endowed CFs with reliable magnetic targeting ability. More encouragingly, the CFs also showed extraordinary angiogenic performance, thus opening up the prospect of its clinical application.
一种双响应（近红外、交变磁场）多功能纳米平台，是基于载尿激酶纤溶酶原激活剂（uPA）的金属有机骨架（MOF）衍生碳纳米材料（以下简称 uPA@CFs）构建的，用于溶栓治疗。载于介孔 CFs 中的 uPA 可在近红外（NIR）介导的热疗作用下释放，以实现浅表溶栓。更重要的是，在交变磁场（AMF）的辅助下，该系统还可以精确加热深部组织区域的血栓。定量实验证明，该双响应系统在深静脉血栓形成中的溶栓效率是单纯近红外光的近 6 倍。这是 MOF 衍生碳纳米材料在靶向溶栓领域的首次应用。令我们高兴的是，MOF 衍生的碳纳米材料（CFs）不仅保持了载药能力，而且赋予了 CFs 可靠的磁靶向能力。更令人鼓舞的是，CFs 还表现出非凡的血管生成性能，从而为其临床应用开辟了前景。
