Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, Korea.
PENS Co., Ltd., Seoul, Korea.
J Med Food. 2021 May;24(5):497-504. doi: 10.1089/jmf.2020.4876.
Previously, we reported that the administration of a mixture of (MH) increased the longitudinal bone growth rate in Sprague Dawley rats. In this study, we investigated the effects of the dietary administration of MH on longitudinal bone growth in growth hormone (GH)-deficient hypophysectomized male and female rats to determine whether the effect of MH was similar to that of GH. We measured the nose-to-anus and nose-to-tail length gain, femur and tibia lengths, growth plate zones, and expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) after the dietary administration of MH or the injection of GH into hypophysectomized rats for 4 weeks. Results demonstrated that the dietary administration of MH had no effect on longitudinal bone growth, whereas the injection of GH increased the nose-to-tail length gain and femur and tibia lengths in hypophysectomized rats. In addition, MH did not affect the growth plate, bone mineralization, and expression of and . These findings indicate that MH does not exert a GH-like effect and that the effects of MH and GH on longitudinal bone growth involve different pathways.
此前，我们报道了 administration of a mixture of （MH）可增加 Sprague Dawley 大鼠的纵向骨生长速度。在这项研究中，我们研究了 MH 饮食对生长激素（GH）缺乏性垂体切除雄性和雌性大鼠纵向骨生长的影响，以确定 MH 的作用是否与 GH 相似。我们测量了饮食给予 MH 或向垂体切除大鼠注射 GH 4 周后，鼻子到肛门和鼻子到尾巴的长度增加、股骨和胫骨长度、生长板区域以及胰岛素样生长因子-1（IGF-1）和胰岛素样生长因子结合蛋白-3（IGFBP-3）的表达。结果表明，MH 的饮食给予对纵向骨生长没有影响，而 GH 的注射增加了垂体切除大鼠的鼻子到尾巴的长度增加以及股骨和胫骨长度。此外，MH 不影响生长板、骨矿化以及 和 的表达。这些发现表明，MH 不发挥 GH 样作用，MH 和 GH 对纵向骨生长的影响涉及不同的途径。
