Suppr超能文献

通过用户推荐和更严格的隔离来提高接触者追踪应用的效果。

Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining.

机构信息

Department of Computer Science, University of Oxford, Oxford, United Kingdom.

Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, Netherlands.

出版信息

PLoS One. 2021 May 19;16(5):e0250435. doi: 10.1371/journal.pone.0250435. eCollection 2021.

Abstract

We study the effects of two mechanisms which increase the efficacy of contact-tracing applications (CTAs) such as the mobile phone contact-tracing applications that have been used during the COVID-19 epidemic. The first mechanism is the introduction of user referrals. We compare four scenarios for the uptake of CTAs-(1) the p% of individuals that use the CTA are chosen randomly, (2) a smaller initial set of randomly-chosen users each refer a contact to use the CTA, achieving p% in total, (3) a small initial set of randomly-chosen users each refer around half of their contacts to use the CTA, achieving p% in total, and (4) for comparison, an idealised scenario in which the p% of the population that uses the CTA is the p% with the most contacts. Using agent-based epidemiological models incorporating a geometric space, we find that, even when the uptake percentage p% is small, CTAs are an effective tool for mitigating the spread of the epidemic in all scenarios. Moreover, user referrals significantly improve efficacy. In addition, it turns out that user referrals reduce the quarantine load. The second mechanism for increasing the efficacy of CTAs is tuning the severity of quarantine measures. Our modelling shows that using CTAs with mild quarantine measures is effective in reducing the maximum hospital load and the number of people who become ill, but leads to a relatively high quarantine load, which may cause economic disruption. Fortunately, under stricter quarantine measures, the advantages are maintained but the quarantine load is reduced. Our models incorporate geometric inhomogeneous random graphs to study the effects of the presence of super-spreaders and of the absence of long-distant contacts (e.g., through travel restrictions) on our conclusions.

摘要

我们研究了两种机制对接触者追踪应用程序(CTA)效果的影响,这些机制可以提高 CTA 的效果,例如在 COVID-19 疫情期间使用的手机接触者追踪应用程序。第一种机制是引入用户推荐。我们比较了 CTA 采用的四种情况:(1) 随机选择 p%的个体使用 CTA;(2) 一组较小的随机选择的用户,每个用户推荐一个联系人使用 CTA,总共达到 p%;(3) 一组较小的随机选择的用户,每个用户推荐大约一半的联系人使用 CTA,总共达到 p%;(4) 相比之下,一个理想化的情况是,使用 CTA 的人口比例是接触者最多的人口比例。使用包含几何空间的基于代理的流行病学模型,我们发现,即使采用率 p%很小,CTA 也是减轻疫情传播的有效工具。此外,用户推荐显著提高了效率。此外,事实证明,用户推荐减少了隔离负担。第二种提高 CTA 效果的机制是调整隔离措施的严重程度。我们的模型表明,使用轻度隔离措施的 CTA 可以有效降低最大医院负荷和发病人数,但会导致相对较高的隔离负担,这可能会导致经济中断。幸运的是,在更严格的隔离措施下,优势得以保持,但隔离负担减轻。我们的模型结合了几何非均匀随机图,以研究超级传播者的存在以及长距离接触(例如通过旅行限制)的缺失对我们结论的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575b/8133478/5444b9ad5623/pone.0250435.g001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验