长链非编码 RNA 在骨关节炎中的作用（综述）。
Roles of long non‑coding RNA in osteoarthritis (Review).
机构信息
Department of Joint Surgery, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China.
出版信息
Int J Mol Med. 2021 Jul;48(1). doi: 10.3892/ijmm.2021.4966. Epub 2021 May 20.
Abstract
Osteoarthritis (OA) is a chronic bone and joint disease characterized by articular cartilage degeneration and joint inflammation and is the most common form of arthritis. The clinical manifestations of OA are chronic pain and joint activity disorder, which severely affect the patient quality of life. Long non‑coding RNA (lncRNA) is a class of RNA molecules >200 nucleotides long that are expressed in animals, plants, yeast, prokaryotes and viruses. lncRNA molecules lack an open reading frame and are not translated into protein. The present review collated the results of recent studies on the role of lncRNA in the pathogenesis of OA to provide information for the prevention, diagnosis and treatment of OA.
摘要
骨关节炎（OA）是一种慢性骨骼和关节疾病，其特征为关节软骨退化和关节炎症，是最常见的关节炎类型。OA 的临床表现为慢性疼痛和关节活动障碍，严重影响患者的生活质量。长链非编码 RNA（lncRNA）是一类长度大于 200 个核苷酸的 RNA 分子，在动物、植物、酵母、原核生物和病毒中表达。lncRNA 分子缺乏开放阅读框，不翻译成蛋白质。本综述对 lncRNA 在 OA 发病机制中的作用的最新研究结果进行了整理，以期为 OA 的预防、诊断和治疗提供信息。
相似文献
1
Roles of long non‑coding RNA in osteoarthritis (Review).长链非编码 RNA 在骨关节炎中的作用（综述）。
Int J Mol Med. 2021 Jul;48(1). doi: 10.3892/ijmm.2021.4966. Epub 2021 May 20.
2
The role and function of long non-coding RNAs in osteoarthritis.长链非编码 RNA 在骨关节炎中的作用和功能。
Exp Mol Pathol. 2020 Jun;114:104407. doi: 10.1016/j.yexmp.2020.104407. Epub 2020 Feb 21.
3
Advances in Research on the Regulatory Roles of lncRNAs in Osteoarthritic Cartilage.长链非编码 RNA 在骨关节炎软骨中调控作用的研究进展。
Biomolecules. 2023 Mar 23;13(4):580. doi: 10.3390/biom13040580.
4
Long noncoding RNAs in osteoarthritis.长链非编码 RNA 在骨关节炎中的作用。
Joint Bone Spine. 2017 Oct;84(5):553-556. doi: 10.1016/j.jbspin.2016.09.006. Epub 2016 Dec 3.
5
Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis.长链非编码 RNA 与软骨损伤有关，可促进骨关节炎软骨细胞细胞外基质降解。
Arthritis Rheumatol. 2014 Apr;66(4):969-78. doi: 10.1002/art.38309.
6
LncRNA PVT1 Regulates Chondrocyte Apoptosis in Osteoarthritis by Acting as a Sponge for miR-488-3p.长链非编码RNA PVT1通过作为miR-488-3p的海绵来调节骨关节炎中的软骨细胞凋亡。
DNA Cell Biol. 2017 Jul;36(7):571-580. doi: 10.1089/dna.2017.3678. Epub 2017 May 18.
7
Upregulation of long noncoding TNFSF10 contributes to osteoarthritis progression through the miR-376-3p/FGFR1 axis.长链非编码 TNFSF10 的上调通过 miR-376-3p/FGFR1 轴促进骨关节炎进展。
J Cell Biochem. 2019 Dec;120(12):19610-19620. doi: 10.1002/jcb.29267. Epub 2019 Jul 11.
8
LncRNA MALAT1/MiR-145 Adjusts IL-1β-Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis.长链非编码 RNA MALAT1/miR-145 通过调节 ADAMTS5 调控人骨关节炎软骨细胞 IL-1β诱导的活力和软骨基质降解。
Yonsei Med J. 2019 Nov;60(11):1081-1092. doi: 10.3349/ymj.2019.60.11.1081.
9
Long noncoding RNA TM1P3 is involved in osteoarthritis by mediating chondrocyte extracellular matrix degradation.长链非编码 RNA TM1P3 通过介导软骨细胞细胞外基质降解参与骨关节炎。
J Cell Biochem. 2019 Aug;120(8):12702-12712. doi: 10.1002/jcb.28539. Epub 2019 Mar 19.
10
LncRNA-CIR promotes articular cartilage degeneration in osteoarthritis by regulating autophagy.长链非编码 RNA-CIR 通过调控自噬促进骨关节炎关节软骨退变。
Biochem Biophys Res Commun. 2018 Nov 2;505(3):692-698. doi: 10.1016/j.bbrc.2018.09.163. Epub 2018 Oct 3.
引用本文的文献
1
Identification of WDR74 and TNFRSF12A as biomarkers for early osteoarthritis using machine learning and immunohistochemistry.利用机器学习和免疫组织化学鉴定WDR74和TNFRSF12A作为早期骨关节炎的生物标志物。
Front Immunol. 2025 Jan 28;16:1517646. doi: 10.3389/fimmu.2025.1517646. eCollection 2025.
2
Progress in multi-omics studies of osteoarthritis.骨关节炎的多组学研究进展
Biomark Res. 2025 Feb 11;13(1):26. doi: 10.1186/s40364-025-00732-y.
3
Deciphering the Role of LncRNAs in Osteoarthritis: Inflammatory Pathways Unveiled.解读长链非编码RNA在骨关节炎中的作用：揭示炎症途径
J Inflamm Res. 2024 Sep 20;17:6563-6581. doi: 10.2147/JIR.S489682. eCollection 2024.
4
Bibliometric analysis of synovial in osteoarthritis in the last 10 years.过去10年骨关节炎中滑膜的文献计量分析。
Heliyon. 2024 Jun 21;10(13):e33406. doi: 10.1016/j.heliyon.2024.e33406. eCollection 2024 Jul 15.
5
Identifying autophagy-related mRNAs and potential ceRNA networks in meniscus degeneration based on RNA sequencing and experimental validation.基于RNA测序和实验验证鉴定半月板退变中自噬相关mRNA及潜在的ceRNA网络。
Heliyon. 2024 Jun 12;10(12):e32782. doi: 10.1016/j.heliyon.2024.e32782. eCollection 2024 Jun 30.
6
LncRNA: A multifunctional key player in non-oncological pathological conditions.长链非编码RNA：非肿瘤性病理状况中的多功能关键因子。
Noncoding RNA Res. 2024 Jan 20;9(2):447-462. doi: 10.1016/j.ncrna.2024.01.011. eCollection 2024 Jun.
7
LncRNA THRIL Functions as a Marker for Carotid Artery Stenosis and Affects the Biological Function of Human Aortic Endothelial Cell.长链非编码RNA THRIL作为颈动脉狭窄的标志物发挥作用，并影响人主动脉内皮细胞的生物学功能。
J Inflamm Res. 2023 Jun 8;16:2437-2446. doi: 10.2147/JIR.S409679. eCollection 2023.
8
Role of non‑coding RNAs in cartilage endplate (Review).非编码RNA在软骨终板中的作用（综述）
Exp Ther Med. 2023 May 11;26(1):312. doi: 10.3892/etm.2023.12011. eCollection 2023 Jul.
9
Advances in Research on the Regulatory Roles of lncRNAs in Osteoarthritic Cartilage.长链非编码 RNA 在骨关节炎软骨中调控作用的研究进展。
Biomolecules. 2023 Mar 23;13(4):580. doi: 10.3390/biom13040580.
10
Osteopontin: A Bone-Derived Protein Involved in Rheumatoid Arthritis and Osteoarthritis Immunopathology.骨桥蛋白：一种参与类风湿关节炎和骨关节炎免疫病理学的骨源性蛋白。
Biomolecules. 2023 Mar 9;13(3):502. doi: 10.3390/biom13030502.
本文引用的文献
1
LncRNA MALAT1 promotes osteoarthritis by modulating miR-150-5p/AKT3 axis.长链非编码RNA MALAT1通过调节miR-150-5p/AKT3轴促进骨关节炎。
Cell Biosci. 2019 Jul 1;9:54. doi: 10.1186/s13578-019-0302-2. eCollection 2019.
2
LncRNA MEG3 Inhibits the Degradation of the Extracellular Matrix of Chondrocytes in Osteoarthritis via Targeting miR-93/TGFBR2 Axis.长链非编码 RNA MEG3 通过靶向 miR-93/TGFBR2 轴抑制骨关节炎软骨细胞细胞外基质的降解。
Cartilage. 2021 Dec;13(2_suppl):1274S-1284S. doi: 10.1177/1947603519855759. Epub 2019 Jun 28.
3
Silence of lncRNA MIAT protects ATDC5 cells against lipopolysaccharides challenge via up-regulating miR-132.长链非编码 RNA MIAT 的沉默通过上调 miR-132 来保护 ATDC5 细胞免受脂多糖的挑战。
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2521-2527. doi: 10.1080/21691401.2019.1626410.
4
Long non-coding RNA XIST promotes extracellular matrix degradation by functioning as a competing endogenous RNA of miR-1277-5p in osteoarthritis.长链非编码 RNA XIST 通过作为 miR-1277-5p 的竞争性内源性 RNA 促进骨关节炎细胞外基质降解。
Int J Mol Med. 2019 Aug;44(2):630-642. doi: 10.3892/ijmm.2019.4240. Epub 2019 Jun 12.
5
LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression.长链非编码 RNA PACER 在骨关节炎中表达下调，调节软骨细胞凋亡和长链非编码 RNA HOTAIR 的表达。
Biosci Rep. 2019 Jun 7;39(6). doi: 10.1042/BSR20190404. Print 2019 Jun 28.
6
LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis.长链非编码 RNA CASC2 在骨关节炎中上调，并参与调节 IL-17 的表达以及软骨细胞的增殖和凋亡。
Biosci Rep. 2019 May 14;39(5). doi: 10.1042/BSR20182454. Print 2019 May 31.
7
Long non-coding RNA highly up-regulated in liver cancer protects tumor necrosis factor-alpha-induced inflammatory injury by down-regulation of microRNA-101 in ATDC5 cells.长链非编码 RNA 在肝癌中高表达，通过下调 ATDC5 细胞中的 microRNA-101 来保护肿瘤坏死因子-α诱导的炎症损伤。
Int Immunopharmacol. 2019 Jul;72:148-158. doi: 10.1016/j.intimp.2019.04.004. Epub 2019 Apr 10.
8
LncRNA FOXD2-AS1 induces chondrocyte proliferation through sponging miR-27a-3p in osteoarthritis.长链非编码 RNA FOXD2-AS1 通过海绵吸附 miR-27a-3p 诱导骨关节炎软骨细胞增殖。
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1241-1247. doi: 10.1080/21691401.2019.1596940.
9
Knockdown of LncRNA H19 Relieves LPS-Induced Damage by Modulating miR-130a in Osteoarthritis.下调LncRNA H19通过调节骨关节炎中的miR-130a减轻脂多糖诱导的损伤。
Yonsei Med J. 2019 Apr;60(4):381-388. doi: 10.3349/ymj.2019.60.4.381.
10
Long non-coding RNA activated by transforming growth factor beta alleviates lipopolysaccharide-induced inflammatory injury via regulating microRNA-223 in ATDC5 cells.转化生长因子 β 激活的长非编码 RNA 通过调节 ATDC5 细胞中的 microRNA-223 缓解脂多糖诱导的炎症损伤。
Int Immunopharmacol. 2019 Apr;69:313-320. doi: 10.1016/j.intimp.2019.01.056. Epub 2019 Feb 13.
Zotero 插件