长链非编码 RNA 在骨关节炎中的作用和功能。
The role and function of long non-coding RNAs in osteoarthritis.
机构信息
Department of Internal Medicine, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Family Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Clinical Research Development Unit, Ali Ibn Abi Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
出版信息
Exp Mol Pathol. 2020 Jun;114:104407. doi: 10.1016/j.yexmp.2020.104407. Epub 2020 Feb 21.
Osteoarthiritis (OA) is the most prevalent disease of articulating joints in human that frequently results in joint pain, movement limitations, inflammation, and progressive degradation of articular cartilage. The etiology of OA is not completely clear and there is no full treatment for this disease. Molecular investigations have revealed the involvement of non-coding RNAs such as Long non-coding RNAs (lncRNAs) in OA pathogenesis. LncRNAs play roles in multiple cellular and biological processes. Moreover, numerous lncRNAs are differentially expressed in human OA cartilage. In this review, we underlie the increasing evidence for the critical role of lncRNAs in OA pathogenesis reviewing the latest researches.
骨关节炎（OA）是人类关节中最常见的疾病，常导致关节疼痛、运动受限、炎症和关节软骨的进行性退化。OA 的病因尚不完全清楚，目前尚无针对这种疾病的完全治疗方法。分子研究表明，非编码 RNA 如长非编码 RNA（lncRNAs）参与了 OA 的发病机制。lncRNAs 在多种细胞和生物过程中发挥作用。此外，大量的 lncRNAs 在人类 OA 软骨中表达不同。在这篇综述中，我们强调了 lncRNAs 在 OA 发病机制中的关键作用的新证据，综述了最新的研究。
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