Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt.
Department of Family Medicine, Suez Canal University, Ismailia, Egypt.
Cancer Rep (Hoboken). 2021 Oct;4(5):e1379. doi: 10.1002/cnr2.1379. Epub 2021 May 20.
Colorectal cancer is one of the most common cancers and the leading cause of cancer-related death worldwide. Early diagnostic methods help in therapeutic success and higher survival rate. Golgi protein 73 (gp73) could help in diagnosis of colorectal cancer at an earlier stage.
A case-control study aimed to assess serum level of golgi protein 73 (gp73) as a liquid biopsy marker in Egyptian colorectal cancer patients.
In the current study, ninty (90) patients were included and classified into three groups; thirty (30) patients with Colorectal cancer (CRC) as study group; 30 patients (20 patients with irritable bowel disease and 10 patients with rectal polyps) as pathological control and 30 healthy adult individuals as normal control. The diagnosis was based on the history, clinical, laboratory, endoscopic, and histological data. Golgiprotein 73 (GP73) was measured by ELISA immunoassay Kit. Serum GP73 level was higher in CRC patients than pathological control group and normal control group with high sensitivity and specificity p < .005.
GP73 alone or combined with Carcinoembryonic antigen (CEA) may be good diagnositic marker in CRC. However large studies are warranted on different stages of the disease to assess its diagnostic and prognositic value.
结直肠癌是最常见的癌症之一，也是全球癌症相关死亡的主要原因。早期诊断方法有助于提高治疗成功率和生存率。高尔基糖蛋白 73（gp73）有助于更早地诊断结直肠癌。
本病例对照研究旨在评估高尔基糖蛋白 73（gp73）作为埃及结直肠癌患者液体活检标志物的血清水平。
在本研究中，共纳入 90 例患者，并分为三组：30 例结直肠癌（CRC）患者为研究组；30 例（20 例为肠易激综合征患者，10 例为直肠息肉患者）为病理对照组，30 例健康成年人作为正常对照组。诊断基于病史、临床、实验室、内镜和组织学数据。采用 ELISA 免疫检测试剂盒检测高尔基糖蛋白 73（GP73）。CRC 患者的血清 GP73 水平高于病理对照组和正常对照组，具有较高的敏感性和特异性（p<.005）。
GP73 单独或与癌胚抗原（CEA）联合检测可能是 CRC 的良好诊断标志物。然而，需要在疾病的不同阶段进行更大规模的研究，以评估其诊断和预后价值。
