Atherton D J, Carabott F, Glover M T, Hawk J L
Department of Paediatric Dermatology, St. John's Hospital for Diseases of the Skin, London, U.K.
Br J Dermatol. 1988 Jun;118(6):791-5. doi: 10.1111/j.1365-2133.1988.tb02597.x.
Fifteen adolescent children with severe, persistent atopic eczema were treated with oral psoralen photochemotherapy (PUVA). This resulted in initial clearance of eczema in 14 of the 15 children, nine of whom achieved a remission. Apart from its effectiveness, a major benefit of this therapeutic approach was that it was associated with resumption of normal growth in children who were previously growing poorly, either as a direct result of severe eczema or its treatment. Nevertheless, against the considerable advantages of PUVA for this group of patients have to be balanced the possible hazards, because relatively high exposures are required in some individuals, both initially to induce clearance and subsequently to maintain it.
15名患有严重、持续性特应性皮炎的青少年儿童接受了口服补骨脂素光化学疗法（PUVA）治疗。这使得15名儿童中的14名最初的湿疹得到清除，其中9名实现了缓解。除了其有效性外，这种治疗方法的一个主要益处是，它与之前生长发育不良的儿童恢复正常生长有关，这些儿童生长发育不良要么是严重湿疹的直接结果，要么是其治疗的结果。然而，对于这组患者，PUVA的诸多优点必须与可能的风险相权衡，因为在一些个体中需要相对较高的照射剂量，最初用于诱导清除，随后用于维持清除效果。
