Huang Gen, Fang Nian, Kuang Meng-Qi, Huang Ya-Qin, Zhang Kun-He
Department of Gastroenterology, The Third Affiliated Hospital of Nanchang University Nanchang 330008, Jiangxi Province, China.
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Jiangxi Institute for Digestive Diseases Nanchang 330006, Jiangxi Province, China.
Am J Transl Res. 2021 Apr 15;13(4):2969-2975. eCollection 2021.
To investigate the establishment of a risk assessment system for peptic ulcer (PU) recurrence and implement an individualized intervention for PU patients with a moderate to high recurrence risk to reduce the recurrence of PU in patients with a moderate to high recurrence risk.
The factors for PU recurrence were collected through consulting the literature, and a risk prediction model for PU recurrence was established using the univariate binary and multivariate multinomial Logistic stepwise regression analysis. According to the model, a total of 235 PU patients were divided into patients with high, moderate and low recurrence risks. A total of 71 PU patients with moderate to high recurrence risks were selected as the study subjects, and further divided into the control group (n=35) and the experimental group (n=36). The control group was not treated with intervention, while the experimental group was treated with individualized intervention. The PU recurrence, adverse emotions and changes of pain degree were assessed in the two groups at 3, 6, 9 and 12 months after intervention.
The univariate and multivariate Logistic regression analysis showed that drinking alcohol, smoking, chronic diseases, oral NSAIDS and depression were associated with the recurrence of PU. Individualized intervention improved the recurrence rate, anxiety, depression, pain degree and quality of life of patients with moderate to high PU recurrence risk.
Drinking alcohol, smoking, chronic diseases, oral NSAIDS and depression were associated with the recurrence of PU. Individualized intervention can improve the quality of prognosis and the recurrence risk of PU in patients, which has positive clinical significance.
探讨建立消化性溃疡（PU）复发风险评估体系，并对复发风险中、高的PU患者实施个体化干预，以降低复发风险中、高患者的PU复发率。
通过查阅文献收集PU复发的相关因素，采用单因素二元及多因素多项Logistic逐步回归分析建立PU复发风险预测模型。根据该模型，将235例PU患者分为复发风险高、中、低3组。选取71例复发风险中、高的PU患者作为研究对象，进一步分为对照组（n = 35）和试验组（n = 36）。对照组未进行干预治疗，试验组给予个体化干预。干预后3、6、9、12个月评估两组患者的PU复发情况、不良情绪及疼痛程度变化。
单因素及多因素Logistic回归分析显示，饮酒、吸烟、慢性病、口服非甾体抗炎药（NSAIDS）及抑郁与PU复发有关。个体化干预改善了复发风险中、高的PU患者的复发率、焦虑、抑郁、疼痛程度及生活质量。
饮酒、吸烟、慢性病、口服NSAIDS及抑郁与PU复发有关。个体化干预可改善患者的预后质量及PU复发风险，具有积极的临床意义。
