油棕和巴西棕在大鼠消化性溃疡防治中的活性

ACTIVITY OF ORBIGNYA PHALERATA AND EUTERPE EDULES IN THE PREVENTION AND TREATMENT OF PEPTIC ULCER IN RATS.

作者信息

Torres Orlando Jorge Martins, Santos Orlando José Dos, Moura Roberto Soares de, Serra Humberto Oliveira, Ramos Vanisse Portela, Melo Syomara Pereira da Costa, Loureiro Carlos Manoel Bulcão

机构信息

Department of Surgery, Federal University of Maranhão, São Luís, MA.

Department of Pharmacology, State University of Rio de Janeiro, Rio de Janeiro, RJ.

出版信息

Arq Bras Cir Dig. 2018 Aug 16;31(3):e1390. doi: 10.1590/0102-672020180001e1390.

DOI:10.1590/0102-672020180001e1390

PMID:30133682

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6097162/

Abstract

BACKGROUND

Peptic ulcer is considered a public health problem associated with loss of quality of life. Does not exist optimal therapeutic regimen. The search for alternative treatments using foods or plants that may assist in gastric protection may become marked in this population because of their easy access and low cost.

AIM

To study the antiulcerogenic activity of extracts of Orbignya phalerata (babaçu) and Euterpe edules (juçara) in Wistar rats after induction of peptic ulcer, compared with Omeprazole.

METHOD

Forty Wistar rats were distributed into four groups: group I, II, III, IV (10 rats each) subjected to extract of Orbignya phalerata, Euterpe edules, Omeprazole and ethanol, respectively. Each group of 10 rats was divided into subgroups of five for prophylaxis and therapeutic study.

RESULTS

The pre-treatment with juçara extract has provided a significant protection against peptic ulcer induced by ethanol. In the prophylactic subgroup, Omeprazole resulted in protection. In addition to protection against peptic ulcer, inflammation and neocapillarization were also variables with a statistical significance in the prophylaxis subgroups using omeprazole and juçara. In the therapeutic subgroup, omeprazole, juçara and babaçu were statistically different as for protection against the presence of inflammation and the healing of ulcers.

CONCLUSION

The extracts of juçara and babaçu behaved as the omeprazole, evidencing the therapeutic activity of these extracts.

摘要

背景

消化性溃疡被认为是一个与生活质量下降相关的公共卫生问题。不存在最佳治疗方案。由于食物或植物易于获取且成本低廉，寻找可能有助于胃保护的替代治疗方法在这一人群中可能会变得很突出。

目的

与奥美拉唑相比，研究消化性溃疡诱导后，巴西棕榈（Orbignya phalerata）和贾卡拉棕榈（Euterpe edules）提取物在Wistar大鼠中的抗溃疡活性。

方法

将40只Wistar大鼠分为四组：第一组、第二组、第三组、第四组（每组10只大鼠），分别给予巴西棕榈提取物、贾卡拉棕榈提取物、奥美拉唑和乙醇。每组10只大鼠再分为每组5只的亚组进行预防和治疗研究。

结果

用贾卡拉棕榈提取物预处理对乙醇诱导的消化性溃疡有显著保护作用。在预防亚组中，奥美拉唑有保护作用。除了对消化性溃疡有保护作用外，在使用奥美拉唑和贾卡拉棕榈提取物的预防亚组中，炎症和新血管形成也是具有统计学意义的变量。在治疗亚组中，奥美拉唑、贾卡拉棕榈提取物和巴西棕榈提取物在预防炎症和溃疡愈合方面有统计学差异。