体素内不相干运动扩散加权成像（IVIM-DWI）定量参数在前列腺癌诊断价值中的研究
Study on diagnostic value of quantitative parameters of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in prostate cancer.
作者信息
Yao Weigen, Liu Jie, Zheng Jiaju, Lu Pengcong, Zou Shufang, Xu Ying
机构信息
Department of Radiology, Yuyao People's Hospital of Zhejiang Province Yuyao, Zhejiang Province, China.
Department of Urological Surgery, Yuyao People's Hospital of Zhejiang Province Yuyao, Zhejiang Province, China.
出版信息
Am J Transl Res. 2021 Apr 15;13(4):3696-3702. eCollection 2021.
OBJECTIVE
To investigate the diagnostic value of quantitative parameters of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in prostate cancer.
METHODS
From January 2019 to June 2020, 96 patients with prostatic tumor admitted in the department of urological surgery of our hospital were selected as subjects. Magnetic resonance imaging data of 48 cases of benign prostatic hyperplasia and 48 cases of prostate cancer were retrospectively analyzed. The patients included in this study received conventional MRI and IVIM-DWI examinations. Quantitative parameters of IVIM-DWI including D value, D* value, apparent diffusion coefficient (ADC) value and f value in lesions of prostatic tumor were calculated through the double exponential model fitting algorithm. D value, D* value, ADC value and f value were compared between benign prostatic hyperplasia (BPH) group and prostate cancer group. Quantitative parameters of IVIM-DWI were also compared among patients from different Gleason scores groups. The correlation of quantitative parameters of IVIM-DWI with Gleason scores and PSA concentration was analyzed. Diagnostic efficiency of quantitative parameters of IVIM-DWI for prostate cancer was evaluated by ROC curve.
RESULTS
Compared with those in BPH group, D value, ADC value and f value in prostate cancer group were significantly lower, but D* value was obviously higher. With the Gleason score increased, D value, ADC value and f value gradually decreased, while D* value gradually increased. The diagnostic efficiency of parameters ADC and D was higher among other parameters. D value, ADC value and f value of prostate cancer were negatively correlated with Gleason score and PSA concentration, respectively (all P<0.05), while D* value was positively correlated with Gleason score and PSA concentration.
CONCLUSIONS
Quantitative parameters of IVIM-DWI could be used for the diagnosis and evaluation of prostate cancer, and quantitative parameters of IVIM-DWI were associated with Gleason score and PSA concentration.
目的
探讨体素内不相干运动扩散加权成像（IVIM-DWI）定量参数在前列腺癌中的诊断价值。
方法
选取2019年1月至2020年6月在我院泌尿外科住院的96例前列腺肿瘤患者作为研究对象。回顾性分析48例良性前列腺增生和48例前列腺癌患者的磁共振成像数据。本研究纳入的患者均接受了常规MRI和IVIM-DWI检查。通过双指数模型拟合算法计算前列腺肿瘤病灶的IVIM-DWI定量参数，包括D值、D值、表观扩散系数（ADC）值和f值。比较良性前列腺增生（BPH）组和前列腺癌组的D值、D值、ADC值和f值。同时比较不同Gleason评分组患者的IVIM-DWI定量参数。分析IVIM-DWI定量参数与Gleason评分及前列腺特异抗原（PSA）浓度的相关性。采用ROC曲线评估IVIM-DWI定量参数对前列腺癌的诊断效能。
结果
与BPH组相比，前列腺癌组的D值、ADC值和f值显著降低，而D值明显升高。随着Gleason评分升高，D值、ADC值和f值逐渐降低，而D值逐渐升高。其中，ADC和D参数的诊断效能较高。前列腺癌的D值、ADC值和f值分别与Gleason评分和PSA浓度呈负相关（均P<0.05），而D*值与Gleason评分和PSA浓度呈正相关。
结论
IVIM-DWI定量参数可用于前列腺癌的诊断和评估，且IVIM-DWI定量参数与Gleason评分和PSA浓度相关。
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