Division of Stem Cell Regulation and Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
Department of Urology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
J Cell Physiol. 2021 Nov;236(11):7853-7873. doi: 10.1002/jcp.30412. Epub 2021 May 21.
Epidemiological studies have shown that plasma HDL-C levels are closely related to the risk of prostate cancer, breast cancer, and other malignancies. As one of the key carriers of cholesterol regulation, high-density lipoprotein (HDL) plays an important role in tumorigenesis and cancer development through anti-inflammation, antioxidation, immune-modulation, and mediating cholesterol transportation in cancer cells and noncancer cells. In addition, the occurrence and progression of cancer are closely related to the alteration of the tumor microenvironment (TME). Cancer cells synthesize and secrete a variety of cytokines and other factors to promote the reprogramming of surrounding cells and shape the microenvironment suitable for cancer survival. By analyzing the effect of HDL on the infiltrating immune cells in the TME, as well as the relationship between HDL and tumor-associated angiogenesis, it is suggested that a moderate increase in the level of HDL in vivo with consequent improvement of the function of HDL in the TME and induction of intracellular cholesterol efflux may be a promising strategy for cancer therapy.
流行病学研究表明，血浆高密度脂蛋白胆固醇（HDL-C）水平与前列腺癌、乳腺癌和其他恶性肿瘤的风险密切相关。高密度脂蛋白（HDL）作为胆固醇调节的关键载体之一，通过抗炎、抗氧化、免疫调节以及介导癌细胞和非癌细胞中的胆固醇运输，在肿瘤发生和癌症发展中发挥重要作用。此外，癌症的发生和发展与肿瘤微环境（TME）的改变密切相关。癌细胞合成和分泌多种细胞因子和其他因子，促进周围细胞的重编程，并塑造适合癌症生存的微环境。通过分析 HDL 对 TME 中浸润免疫细胞的影响，以及 HDL 与肿瘤相关血管生成的关系，提示体内适度增加 HDL 水平，进而改善 HDL 在 TME 中的功能并诱导细胞内胆固醇外流，可能是癌症治疗的一种有前途的策略。
