睾丸血栓性微血管病：一种未被识别的并发症。
Testicular thrombotic microangiopathy: An unrecognized complication.
机构信息
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
出版信息
Pediatr Blood Cancer. 2021 Aug;68(8):e29128. doi: 10.1002/pbc.29128. Epub 2021 May 21.
Abstract
Thrombotic microangiopathy (TMA) causes global endothelial damage and multiorgan injury. No study has described reproductive organ involvement in TMA. Our study aimed to characterize testicular involvement in TMA. We reviewed autopsies from four patients who underwent hematopoietic cell transplant (HCT) complicated by TMA. Three patients had striking histologic evidence of TMA, while the fourth had normal testicular histology. This suggests that TMA injures the testicles and may adversely affect fertility. There is now an urgent need for a larger analysis of reproductive organ involvement in TMA.
摘要
血栓性微血管病（TMA）可导致全身内皮损伤和多器官损伤。目前尚无研究描述 TMA 对生殖器官的影响。本研究旨在描述 TMA 患者睾丸受累的特征。我们复习了 4 例行造血细胞移植（HCT）后并发 TMA 患者的尸检结果。其中 3 例有明显的 TMA 组织学证据，而第 4 例睾丸组织学正常。这表明 TMA 可损伤睾丸并可能对生育能力产生不利影响。目前迫切需要对 TMA 对生殖器官的影响进行更大规模的分析。
相似文献
1
Testicular thrombotic microangiopathy: An unrecognized complication.睾丸血栓性微血管病：一种未被识别的并发症。
Pediatr Blood Cancer. 2021 Aug;68(8):e29128. doi: 10.1002/pbc.29128. Epub 2021 May 21.
2
Thrombotic Microangiopathy Following Pediatric Autologous Hematopoietic Cell Transplantation: A Report of Significant End-Organ Dysfunction in Eculizumab-Treated Survivors.儿童自体造血细胞移植后血栓性微血管病：依库珠单抗治疗幸存者发生重要终末器官功能障碍的报告。
Biol Blood Marrow Transplant. 2019 May;25(5):e163-e168. doi: 10.1016/j.bbmt.2018.12.840. Epub 2019 Jan 11.
3
Emerging Concepts in Hematopoietic Stem Cell Transplantation-Associated Renal Thrombotic Microangiopathy and Prospects for New Treatments.造血干细胞移植相关性肾血栓性微血管病的新观点与新疗法展望。
Am J Kidney Dis. 2018 Dec;72(6):857-865. doi: 10.1053/j.ajkd.2018.06.013. Epub 2018 Aug 23.
4
A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury.一种新范式：将异基因造血干细胞移植相关血栓性微血管病诊断和管理视为多系统内皮损伤
Blood Rev. 2015 May;29(3):191-204. doi: 10.1016/j.blre.2014.11.001. Epub 2014 Nov 28.
5
Transplantation-Associated Thrombotic Microangiopathy Risk Stratification: Is There a Window of Opportunity to Improve Outcomes?移植相关血栓性微血管病风险分层：是否有改善预后的机会窗口？
Transplant Cell Ther. 2022 Jul;28(7):392.e1-392.e9. doi: 10.1016/j.jtct.2022.04.019. Epub 2022 Apr 29.
6
Intestinal thrombotic microangiopathy: a distinct entity in the spectrum of graft-versus-host disease.肠血栓性微血管病：移植物抗宿主病谱中的一个独特实体。
Int J Hematol. 2019 Nov;110(5):529-532. doi: 10.1007/s12185-019-02750-7. Epub 2019 Oct 4.
7
Abnormalities in the alternative pathway of complement in children with hematopoietic stem cell transplant-associated thrombotic microangiopathy.造血干细胞移植相关性血栓性微血管病患儿补体旁路途径的异常。
Blood. 2013 Sep 19;122(12):2003-7. doi: 10.1182/blood-2013-05-501445. Epub 2013 Jun 27.
8
Transplant-associated thrombotic microangiopathy: elucidating prevention strategies and identifying high-risk patients.移植相关性血栓性微血管病：阐明预防策略并确定高危患者。
Expert Rev Hematol. 2021 Aug;14(8):751-763. doi: 10.1080/17474086.2021.1960816. Epub 2021 Aug 4.
9
Early Increase in Complement Terminal Pathway Activation Marker sC5b-9 Is Predictive for the Development of Thrombotic Microangiopathy after Stem Cell Transplantation.早期补体末端途径激活标志物 sC5b-9 的增加可预测干细胞移植后血栓性微血管病的发生。
Biol Blood Marrow Transplant. 2018 May;24(5):989-996. doi: 10.1016/j.bbmt.2018.01.009. Epub 2018 Jan 12.
10
New approaches in the diagnosis, pathophysiology, and treatment of pediatric hematopoietic stem cell transplantation-associated thrombotic microangiopathy.儿童造血干细胞移植相关血栓性微血管病的诊断、病理生理学及治疗新方法
Transfus Apher Sci. 2016 Apr;54(2):181-90. doi: 10.1016/j.transci.2016.04.007. Epub 2016 Apr 25.
引用本文的文献
1
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.协调移植相关性血栓性微血管病的诊断标准和预后评估定义：欧洲血液和骨髓移植学会、美国移植和细胞治疗学会、亚太血液和骨髓移植学会以及国际血液和骨髓移植研究中心的报告。
Transplant Cell Ther. 2023 Mar;29(3):151-163. doi: 10.1016/j.jtct.2022.11.015. Epub 2022 Nov 25.
2
Cerebral vascular injury in transplant-associated thrombotic microangiopathy.移植相关性血栓性微血管病中的脑血管损伤。
Blood Adv. 2022 Jul 26;6(14):4310-4319. doi: 10.1182/bloodadvances.2022007453.
本文引用的文献
1
Complement blockade for TA-TMA: lessons learned from a large pediatric cohort treated with eculizumab.补体阻断治疗 TA-TMA：依库珠单抗治疗的大型儿科队列中获得的经验教训。
Blood. 2020 Mar 26;135(13):1049-1057. doi: 10.1182/blood.2019004218.
2
Complement in Pathophysiology and Treatment of Transplant-Associated Thrombotic Microangiopathies.补体在移植相关性血栓性微血管病发病机制和治疗中的作用。
Semin Hematol. 2018 Jul;55(3):159-166. doi: 10.1053/j.seminhematol.2018.04.003. Epub 2018 Apr 11.
3
Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update.癌症患者的生育力保存：ASCO 临床实践指南更新。
J Clin Oncol. 2018 Jul 1;36(19):1994-2001. doi: 10.1200/JCO.2018.78.1914. Epub 2018 Apr 5.
4
Thrombotic Microangiopathy and the Kidney.血栓性微血管病与肾脏。
Clin J Am Soc Nephrol. 2018 Feb 7;13(2):300-317. doi: 10.2215/CJN.00620117. Epub 2017 Oct 17.
5
Fertility counseling and preservation practices in youth with lupus and vasculitis undergoing gonadotoxic therapy.接受性腺毒性治疗的狼疮和血管炎青年患者的生育咨询与保存措施
Fertil Steril. 2016 Nov;106(6):1470-1474. doi: 10.1016/j.fertnstert.2016.07.1102. Epub 2016 Aug 10.
6
Male fertility potential alteration in rheumatic diseases: a systematic review.风湿性疾病中男性生育潜力的改变：一项系统综述。
Int Braz J Urol. 2016 Jan-Feb;42(1):11-21. doi: 10.1590/S1677-5538.IBJU.2014.0595.
7
A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury.一种新范式：将异基因造血干细胞移植相关血栓性微血管病诊断和管理视为多系统内皮损伤
Blood Rev. 2015 May;29(3):191-204. doi: 10.1016/j.blre.2014.11.001. Epub 2014 Nov 28.
8
Syndromes of thrombotic microangiopathy.血栓性微血管病综合征
N Engl J Med. 2014 Nov 6;371(19):1847-8. doi: 10.1056/NEJMc1410951.
9
Semen analysis in adolescent cancer patients prior to bone marrow transplantation: when is it too late for fertility preservation?青少年癌症患者在骨髓移植前的精液分析：何时进行生育力保存为时过晚？
Pediatr Blood Cancer. 2013 Jan;60(1):129-32. doi: 10.1002/pbc.24172. Epub 2012 May 3.
Zotero 插件