CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Adv Healthc Mater. 2021 Jun;10(12):e2100078. doi: 10.1002/adhm.202100078. Epub 2021 May 21.
Lung cancer is one of the most rapidly growing malignancies in terms of morbidity and mortality. Although traditional treatments have been used for more than 50 years, it is still far from solving the problems of postoperative risks and systemic toxicity. Emerging targeting and immunotherapy are developing continuously and are gaining recognition; eventually, they face the inevitable challenge of drug resistance. Nanotechnology has several important effects on lung cancer treatment, owing to its unique properties. Several nanoparticle-based treatments have successfully become cancer treatments. Good biocompatibility with higher specific surface area can carry substantial amounts of lung cancer treatment medications while avoiding medication toxicity; editable and modified characteristics give rise to multifunctional nanomedicines; excellent photoelectric effects make lung cancer a multimodal treatment. This article summarizes the breakthroughs achieved by nanotechnology, targeted therapy, and immunotherapy, reflecting the importance and necessity of nanotechnology in the treatment of lung cancer.
肺癌是发病率和死亡率增长最快的恶性肿瘤之一。虽然传统的治疗方法已经使用了 50 多年，但仍远未解决术后风险和全身毒性的问题。新兴的靶向治疗和免疫治疗正在不断发展，并逐渐得到认可；最终，它们都面临着药物耐药性的必然挑战。由于其独特的性质，纳米技术对肺癌的治疗有几个重要的影响。几种基于纳米粒子的治疗方法已成功地成为癌症治疗方法。良好的生物相容性和更高的比表面积可以携带大量的肺癌治疗药物，同时避免药物毒性；可编辑和可修改的特性产生了多功能纳米药物；出色的光电效应使肺癌成为一种多模式治疗方法。本文总结了纳米技术、靶向治疗和免疫治疗的突破，反映了纳米技术在肺癌治疗中的重要性和必要性。
