用 TRAFTACs 驯化转录因子。

Taming transcription factors with TRAFTACs.

机构信息

Department of Chemistry, Stanford University, Stanford, CA, USA.

Department of Chemistry, Stanford University, Stanford, CA, USA; Stanford ChEM-H, Stanford University, Stanford, CA, USA.

出版信息

Cell Chem Biol. 2021 May 20;28(5):588-590. doi: 10.1016/j.chembiol.2021.04.016.

DOI:10.1016/j.chembiol.2021.04.016

PMID:34019844

Abstract

Transcription factors play central roles in numerous diseases yet are notoriously challenging targets for drug development. In this issue of Cell Chemical Biology, Samarasinghe et al. (2021) describe a modular approach to targeting transcription factors for degradation with TRAFTACs, without the need for extensive ligand development campaigns.

摘要

转录因子在许多疾病中起着核心作用，但却是药物开发中极具挑战性的靶点。在本期《细胞化学生物学》中，Samarasinghe 等人（2021）描述了一种使用 TRAFTACs 靶向转录因子进行降解的模块化方法，而无需进行广泛的配体开发活动。