Lockitch G, Halstead A C, Wadsworth L, Quigley G, Reston L, Jacobson B
Department of Pathology, B.C. Children's Hospital, Vancouver, Canada.
Clin Chem. 1988 Aug;34(8):1625-8.
Age- and sex-specific reference intervals based on the 0.025 and 0.975 fractiles of data derived from a healthy pediatric population are presented for zinc, copper, selenium, iron, ferritin, retinol, alpha-tocopherol, and related analytes in serum. Age was an important covariate for copper, selenium, retinol, and tocopherol, and ferritin in boys. Strong correlations were found between retinol and retinol-binding protein, prealbumin (transthyretin), alpha-tocopherol, and selenium. Tocopherol was highly correlated with both cholesterol and triglycerides. We found no relationship between serum zinc and either retinol or retinol-binding protein. Despite exclusion of children in whom anemia, microcytosis, or variant hemoglobins were found, the 0.025 fractile for iron in several age groups was even less than the concentration considered to indicate poor iron nutritional status.
本文给出了基于健康儿科人群数据的第0.025和第0.975百分位数的血清锌、铜、硒、铁、铁蛋白、视黄醇、α-生育酚及相关分析物的年龄和性别特异性参考区间。年龄是男孩体内铜、硒、视黄醇、生育酚和铁蛋白的重要协变量。视黄醇与视黄醇结合蛋白、前白蛋白（转甲状腺素蛋白）、α-生育酚和硒之间存在强相关性。生育酚与胆固醇和甘油三酯均高度相关。我们发现血清锌与视黄醇或视黄醇结合蛋白之间无关联。尽管排除了患有贫血、小红细胞症或变异血红蛋白的儿童，但几个年龄组中铁的第0.025百分位数甚至低于被认为表明铁营养状况不佳的浓度。
