• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于可编程操纵和多重存储类顺磁空穴和无标记细胞的 Mattertronics

Mattertronics for programmable manipulation and multiplex storage of pseudo-diamagnetic holes and label-free cells.

机构信息

Department of Emerging Materials Science, DGIST, Daegu, Republic of Korea.

Physical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart, Germany.

出版信息

Nat Commun. 2021 May 21;12(1):3024. doi: 10.1038/s41467-021-23251-4.

DOI:10.1038/s41467-021-23251-4
PMID:34021137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8139950/
Abstract

Manipulating and separating single label-free cells without biomarker conjugation have attracted significant interest in the field of single-cell research, but digital circuitry control and multiplexed individual storage of single label-free cells remain a challenge. Herein, by analogy with the electrical circuitry elements and electronical holes, we develop a pseudo-diamagnetophoresis (PsD) mattertronic approach in the presence of biocompatible ferrofluids for programmable manipulation and local storage of single PsD holes and label-free cells. The PsD holes conduct along linear negative micro-magnetic patterns. Further, eclipse diode patterns similar to the electrical diode can implement directional and selective switching of different PsD holes and label-free cells based on the diode geometry. Different eclipse heights and junction gaps influence the switching efficiency of PsD holes for mattertronic circuitry manipulation and separation. Moreover, single PsD holes are stored at each potential well as in an electrical storage capacitor, preventing multiple occupancies of PsD holes in the array of individual compartments due to magnetic Coulomb-like interaction. This approach may enable the development of large programmable arrays of label-free matters with high throughput, efficiency, and reliability as multiplex cell research platforms.

摘要

在单细胞研究领域，无需生物标志物缀合即可操纵和分离单个无标记细胞引起了极大的关注，但数字电路控制和单个无标记细胞的多路复用个体存储仍然是一个挑战。在此，我们通过类比电路元件和电子空穴，在生物相容性铁磁流体的存在下开发了一种拟顺磁电泳（PsD）物质电子学方法，用于可编程操纵和局部存储单个 PsD 空穴和无标记细胞。PsD 空穴沿线性负微磁图案传导。此外，类似于电子二极管的遮光二极管图案可以根据二极管几何形状实现不同 PsD 空穴和无标记细胞的定向和选择性切换。不同的遮光高度和结间隙会影响 PsD 空穴的开关效率，从而实现物质电子学电路的操纵和分离。此外，单个 PsD 空穴被存储在每个势阱中，就像在电存储电容器中一样，防止由于磁库仑样相互作用而导致多个 PsD 空穴占据单个隔室阵列中的位置。这种方法可以实现具有高通量、高效率和可靠性的大型可编程无标记物质阵列的开发，作为多路复用细胞研究平台。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/62afd8a34a80/41467_2021_23251_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/3b17b1ea74a4/41467_2021_23251_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/2bb857ebf0bd/41467_2021_23251_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/6ad33fb5bbc7/41467_2021_23251_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/43c28c90d3d3/41467_2021_23251_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/31b1cd452e35/41467_2021_23251_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/62df9e6721ef/41467_2021_23251_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/7dd683725034/41467_2021_23251_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/9394bd3cf7ea/41467_2021_23251_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/50b7ae2edf6e/41467_2021_23251_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/62afd8a34a80/41467_2021_23251_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/3b17b1ea74a4/41467_2021_23251_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/2bb857ebf0bd/41467_2021_23251_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/6ad33fb5bbc7/41467_2021_23251_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/43c28c90d3d3/41467_2021_23251_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/31b1cd452e35/41467_2021_23251_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/62df9e6721ef/41467_2021_23251_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/7dd683725034/41467_2021_23251_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/9394bd3cf7ea/41467_2021_23251_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/50b7ae2edf6e/41467_2021_23251_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9084/8139950/62afd8a34a80/41467_2021_23251_Fig10_HTML.jpg

相似文献

1
Mattertronics for programmable manipulation and multiplex storage of pseudo-diamagnetic holes and label-free cells.用于可编程操纵和多重存储类顺磁空穴和无标记细胞的 Mattertronics
Nat Commun. 2021 May 21;12(1):3024. doi: 10.1038/s41467-021-23251-4.
2
Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery.自主磁控微机器人通过导航门实现多种生物分子的输送。
Small. 2018 Jun;14(25):e1800504. doi: 10.1002/smll.201800504. Epub 2018 May 8.
3
Multifarious Transit Gates for Programmable Delivery of Bio-functionalized Matters.多功能转运门用于生物功能化物质的可编程输送
Small. 2019 Jul;15(28):e1901105. doi: 10.1002/smll.201901105. Epub 2019 May 6.
4
Diamagnetic repulsion--a versatile tool for label-free particle handling in microfluidic devices.抗磁性排斥——微流控器件中无标记粒子处理的通用工具。
J Chromatogr A. 2009 Dec 25;1216(52):9055-62. doi: 10.1016/j.chroma.2009.06.039. Epub 2009 Jun 18.
5
Label-free separation of nanoscale particles by an ultrahigh gradient magnetic field in a microfluidic device.在微流控装置中利用超高梯度磁场对纳米级颗粒进行无标记分离。
Nanoscale. 2021 Feb 25;13(7):4029-4037. doi: 10.1039/d0nr08383f.
6
Magnetophoretic Micro-Distributor for Controlled Clustering of Cells.磁泳微分配器用于控制细胞的聚集。
Adv Sci (Weinh). 2022 Feb;9(6):e2103579. doi: 10.1002/advs.202103579. Epub 2021 Dec 15.
7
Label-free cellular manipulation and sorting via biocompatible ferrofluids.无标记细胞操控和分选的生物兼容铁磁流体法。
Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21478-83. doi: 10.1073/pnas.0912138106. Epub 2009 Dec 7.
8
High gradient magnetic field microstructures for magnetophoretic cell separation.用于磁泳细胞分离的高梯度磁场微结构
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Aug 1;1027:194-9. doi: 10.1016/j.jchromb.2016.05.046. Epub 2016 Jun 1.
9
Development and characterization of hollow microprobe array as a potential tool for versatile and massively parallel manipulation of single cells.中空微探针阵列的开发与特性研究：一种用于单细胞多功能大规模平行操作的潜在工具
Biomed Microdevices. 2015 Apr;17(2):41. doi: 10.1007/s10544-015-9943-z.
10
Spatial Manipulation of Particles and Cells at Micro- and Nanoscale via Magnetic Forces.基于磁场的微纳尺度下对粒子和细胞的空间操控。
Cells. 2022 Mar 10;11(6):950. doi: 10.3390/cells11060950.

引用本文的文献

1
Integrated Microfluidics for Single-Cell Separation and On-Chip Analysis: Novel Applications and Recent Advances.用于单细胞分离和芯片分析的集成微流控技术：新应用与最新进展
Small Sci. 2024 Feb 2;4(4):2300206. doi: 10.1002/smsc.202300206. eCollection 2024 Apr.
2
Stray Magnetic Field Variations and Micromagnetic Simulations: Models for NiFe Disks Used for Microparticle Trapping.杂散磁场变化与微磁模拟：用于微粒捕获的镍铁磁盘模型
Micromachines (Basel). 2024 Apr 26;15(5):567. doi: 10.3390/mi15050567.
3
Strain-induced self-rolled-up microtubes for multifunctional on-chip microfluidic applications.

本文引用的文献

1
Spatially selective manipulation of cells with single-beam acoustical tweezers.利用单光束声镊对细胞进行空间选择性操作。
Nat Commun. 2020 Aug 25;11(1):4244. doi: 10.1038/s41467-020-18000-y.
2
Acoustic streaming vortices enable contactless, digital control of droplets.声流漩涡实现了对液滴的非接触式数字控制。
Sci Adv. 2020 Jun 10;6(24):eaba0606. doi: 10.1126/sciadv.aba0606. eCollection 2020 Jun.
3
FACS-Based Functional Protein Screening via Microfluidic Co-encapsulation of Yeast Secretor and Mammalian Reporter Cells.基于流式细胞术的功能蛋白筛选：通过微流控共包封酵母分泌细胞和哺乳动物报告细胞
用于多功能片上微流体应用的应变诱导自卷微管
Biomicrofluidics. 2023 Sep 15;17(5):051501. doi: 10.1063/5.0170958. eCollection 2023 Sep.
4
Magnetophoretic circuits: A review of device designs and implementation for precise single-cell manipulation.磁泳电路：用于精确单细胞操作的设备设计和实现综述。
Anal Chim Acta. 2023 Sep 1;1272:341425. doi: 10.1016/j.aca.2023.341425. Epub 2023 May 31.
5
Microelectromechanical Systems Based on Magnetic Polymer Films.基于磁性聚合物薄膜的微机电系统
Micromachines (Basel). 2022 Feb 23;13(3):351. doi: 10.3390/mi13030351.
6
Self-assembled microtubular electrodes for on-chip low-voltage electrophoretic manipulation of charged particles and macromolecules.用于芯片上对带电粒子和大分子进行低压电泳操作的自组装微管电极。
Microsyst Nanoeng. 2022 Feb 28;8:27. doi: 10.1038/s41378-022-00354-6. eCollection 2022.
Sci Rep. 2020 Jun 23;10(1):10182. doi: 10.1038/s41598-020-66927-5.
4
Multifarious Transit Gates for Programmable Delivery of Bio-functionalized Matters.多功能转运门用于生物功能化物质的可编程输送
Small. 2019 Jul;15(28):e1901105. doi: 10.1002/smll.201901105. Epub 2019 May 6.
5
Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery.自主磁控微机器人通过导航门实现多种生物分子的输送。
Small. 2018 Jun;14(25):e1800504. doi: 10.1002/smll.201800504. Epub 2018 May 8.
6
Magnetically Characterized Molecular Lubrication between Biofunctionalized Surfaces.生物功能化表面之间的磁性分子润滑
ACS Appl Mater Interfaces. 2018 May 9;10(18):16177-16182. doi: 10.1021/acsami.8b00903. Epub 2018 Apr 26.
7
Rapid and effective enrichment of mononuclear cells from blood using acoustophoresis.采用声流法从血液中快速有效地富集单核细胞。
Sci Rep. 2017 Dec 7;7(1):17161. doi: 10.1038/s41598-017-17200-9.
8
Synchronous magnetic control of water droplets in bulk ferrofluid. bulk 铁磁流体中液滴的同步磁控。
Soft Matter. 2018 Jan 31;14(5):681-692. doi: 10.1039/c7sm01973d.
9
Particle Manipulation Methods in Droplet Microfluidics.液滴微流控中的粒子操控方法。
Anal Chem. 2018 Feb 6;90(3):1434-1443. doi: 10.1021/acs.analchem.7b01333. Epub 2017 Dec 21.
10
Label-Free Microfluidic Manipulation of Particles and Cells in Magnetic Liquids.磁性液体中颗粒与细胞的无标记微流控操控
Adv Funct Mater. 2016 Jun 14;26(22):3916-3932. doi: 10.1002/adfm.201504178. Epub 2016 Apr 14.